N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide

Base Information

Chemical Name:N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide
CAS No.:120072-08-4
Molecular Formula:C₂₄H₂₈FN₃OS₂
Molecular Weight:457.636
Hs Code.:
Mol file:120072-08-4.mol

Synonyms:N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide;1-(2-(1H-pyrazol-1-yl)ethyl)-4-(4-methylthiazol-2-yl)-4-(N-phenylpropionamide)piperidine

Suppliers and Price of N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide

Chemical Property:

Vapor Pressure:6.19E-14mmHg at 25°C
Melting Point:202-204 °C
Boiling Point:590.8°Cat760mmHg
PKA:7.41±0.20(Predicted)
Flash Point:311.1°C
PSA：92.92000
Density:1.254g/cm³
LogP:5.56700

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide

There total 4 articles about N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122823-36-3
N-(2-Fluoro-phenyl)-N-[4-(4-methyl-thiazol-2-yl)-piperidin-4-yl]-propionamide

: 120072-08-4
N-(2-Fluoro-phenyl)-N-[4-(4-methyl-thiazol-2-yl)-1-(2-thiophen-3-yl-ethyl)-piperidin-4-yl]-propionamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 18h; Heating;
DOI:10.1021/jm00132a007

Reference yield:

: 120070-56-6
1-benzyl-4-(2-fluorophenylamino)piperidine-4-carbonitrile

: 120072-08-4
N-(2-Fluoro-phenyl)-N-[4-(4-methyl-thiazol-2-yl)-1-(2-thiophen-3-yl-ethyl)-piperidin-4-yl]-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / -78 °C

2: CHCl₃ / Heating

3: 1) 1-chloroethyl chloroformate, 2) MeOH / 1) 1,2-dichloroethane, a) 0 deg C, 15 min, b) reflux, 2 h, 2) reflux, 4 h

4: K₂CO₃ / acetonitrile / 18 h / Heating

With methanol; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In tetrahydrofuran; chloroform; acetonitrile;
DOI:10.1021/jm00132a007

Reference yield:

: 120517-24-0
[1-Benzyl-4-(4-methyl-thiazol-2-yl)-piperidin-4-yl]-(2-fluoro-phenyl)-amine

: 120072-08-4
N-(2-Fluoro-phenyl)-N-[4-(4-methyl-thiazol-2-yl)-1-(2-thiophen-3-yl-ethyl)-piperidin-4-yl]-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃ / Heating

2: 1) 1-chloroethyl chloroformate, 2) MeOH / 1) 1,2-dichloroethane, a) 0 deg C, 15 min, b) reflux, 2 h, 2) reflux, 4 h

3: K₂CO₃ / acetonitrile / 18 h / Heating

With methanol; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In chloroform; acetonitrile;
DOI:10.1021/jm00132a007