2-Propenamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidin yl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

Base Information

• Chemical Name: 2-Propenamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidin yl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-
• CAS No.: 595558-98-8
• Molecular Formula: C28H34N4O4
• Molecular Weight: 490.602
• Mol file: 595558-98-8.mol

Synonyms:

Chemical Property of 2-Propenamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidin yl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidin yl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

There total 3 articles about 2-Propenamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidin yl)-3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

5,6-diamino-3-methyl-1-phenyluracil (50786-93-1) + 3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enoic acid (22014-01-3) → 6-amino-5-(3,5-di-tert-butyl-4-hydroxycinnamoylamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (595558-98-8)

Guidance literature:

With triethylamine; Diphenylphosphinic chloride; In ethyl acetate; at 20 ℃;

DOI:10.1248/cpb.51.309

Reference yield:

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (42212-19-1) → 6-amino-5-(3,5-di-tert-butyl-4-hydroxycinnamoylamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (595558-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂; aq. HCl / 20 °C

2: H₂ / 5 percent Pd/C / methanol

3: 36 percent / Et₃N; diphenylphosphoryl chloride / ethyl acetate / 20 °C

With hydrogenchloride; hydrogen; triethylamine; sodium nitrite; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1248/cpb.51.309

Reference yield:

6-amino-3-methyl-5-nitro-1-phenyl-1H-pyrimidine-2,4-dione → 6-amino-5-(3,5-di-tert-butyl-4-hydroxycinnamoylamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (595558-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol

2: 36 percent / Et₃N; diphenylphosphoryl chloride / ethyl acetate / 20 °C

With hydrogen; triethylamine; Diphenylphosphinic chloride; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1248/cpb.51.309

upstream raw materials:

5,6-diamino-3-methyl-1-phenyluracil

3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enoic acid

6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione