Technology Process of 6-(methylsulfonyl)-2-phenyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine
There total 6 articles about 6-(methylsulfonyl)-2-phenyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium peroxomonosulphate;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 71 percent / anhydrous sodium acetate, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 25 deg C, 16 h;
2: 1.) n-butyllithium / 1.) ether, hexane, -70 deg C, 15 min, 2.) -60 deg C;
3: 47 percent / 48percent HBr / acetic acid / 95 - 100 °C
4: 40 percent / H2 / W-2 Raney Nickel / ethanol; tetrahydrofuran
5: 1.) t-butyllithium / 1.) toluene, ether, pentan, -100 deg C, 20 min;
6: 80 percent / potassium persulfate / methanol; tetrahydrofuran; H2O
With
n-butyllithium; potassium peroxomonosulphate; hydrogen bromide; hydrogen; bromine; tert.-butyl lithium; sodium acetate;
W-2 Raney nickel;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 40 percent / H2 / W-2 Raney Nickel / ethanol; tetrahydrofuran
2: 1.) t-butyllithium / 1.) toluene, ether, pentan, -100 deg C, 20 min;
3: 80 percent / potassium persulfate / methanol; tetrahydrofuran; H2O
With
potassium peroxomonosulphate; hydrogen; tert.-butyl lithium;
W-2 Raney nickel;
In
tetrahydrofuran; methanol; ethanol; water;
