N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

Base Information

Chemical Name:N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
CAS No.:595582-79-9
Molecular Formula:C22H26FN5O5S
Molecular Weight:491.543
Hs Code.:
DSSTox Substance ID:DTXSID301037217
Wikidata:Q57415434
ChEMBL ID:CHEMBL307143

Synonyms:YC-20;CHEMBL307143;DTXSID301037217;Q57415434;595582-79-9;N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1- yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5- yl]methyl}acetamide

Suppliers and Price of N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:491.16386828
Heavy Atom Count:34
Complexity:847

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)S(=O)(=O)C4=CC=CC(=C4)N)F
Isomeric SMILES:CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCN(CC3)S(=O)(=O)C4=CC=CC(=C4)N)F

Technology Process of N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

There total 3 articles about N-{[(5S)-3-{4-[4-(3-Aminobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.7%

: 595582-85-7
N-(3-{3-fluoro-4-[4-(3-nitro-benzenesulfonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

: 595582-79-9
N-(3-{4-[4-(3-amino-benzenesulfonyl)-piperazin-1-yl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(03)00430-X

Reference yield:

: 121-51-7
3-nitrobenzenesulphonyl chloride

: 595582-79-9
N-(3-{4-[4-(3-amino-benzenesulfonyl)-piperazin-1-yl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / pyridine / 0 - 20 °C

2: 80.7 percent / H₂ / Pd/C / methanol

With pyridine; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(03)00430-X

Reference yield:

: 154590-66-6,154590-43-9
(S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

: 595582-79-9
N-(3-{4-[4-(3-amino-benzenesulfonyl)-piperazin-1-yl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / pyridine / 0 - 20 °C

2: 80.7 percent / H₂ / Pd/C / methanol

With pyridine; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(03)00430-X