Benzoic acid, 2-[3-nitro-4-oxo-8-(2-propenyl)-4H-1-benzopyran-2-yl]-, phenylmethyl ester

Base Information

• Chemical Name: Benzoic acid, 2-[3-nitro-4-oxo-8-(2-propenyl)-4H-1-benzopyran-2-yl]-, phenylmethyl ester
• CAS No.: 596108-57-5
• Molecular Formula: C26H19NO6
• Molecular Weight: 441.44
• Mol file: 596108-57-5.mol

Synonyms:

Chemical Property of Benzoic acid, 2-[3-nitro-4-oxo-8-(2-propenyl)-4H-1-benzopyran-2-yl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-[3-nitro-4-oxo-8-(2-propenyl)-4H-1-benzopyran-2-yl]-, phenylmethyl ester

There total 4 articles about Benzoic acid, 2-[3-nitro-4-oxo-8-(2-propenyl)-4H-1-benzopyran-2-yl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-[8-allyl-3-chloro-2,3-dihydro-3-nitro-4-oxo-4H-1-benzopyran-2-yl]benzoic acid benzyl ester → 2-[8-allyl-3-nitro-4-oxo-4H-1-benzopyran-2-yl]benzoic acid benzyl ester (596108-57-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1021/jm021109f

Reference yield:

2-Carbobenzoxybenzaldehyde (113674-51-4) → 2-[8-allyl-3-nitro-4-oxo-4H-1-benzopyran-2-yl]benzoic acid benzyl ester (596108-57-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / dimethylammonium chloride; potassium fluoride / xylene / 3 h / Heating

2: 73 percent / triethylamine / tetrahydrofuran / 20 °C

3: 78 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 20 - 55 °C / sonification

4: 60 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran

With potassium fluoride; N,N-dimethylammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; xylene; 2: Michael condensation;

DOI:10.1021/jm021109f

Reference yield:

Z-2-(2-chloro-2-nitroethenyl)benzoic acid benzyl ester (596108-21-3) → 2-[8-allyl-3-nitro-4-oxo-4H-1-benzopyran-2-yl]benzoic acid benzyl ester (596108-57-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / triethylamine / tetrahydrofuran / 20 °C

2: 78 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 20 - 55 °C / sonification

3: 60 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1: Michael condensation;

DOI:10.1021/jm021109f

upstream raw materials:

2-Carbobenzoxybenzaldehyde

Z-2-(2-chloro-2-nitroethenyl)benzoic acid benzyl ester