Carbamic acid, [(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy) methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy) methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester
CAS No.:596128-78-8
Molecular Formula:C39H49NO6Si
Molecular Weight:655.907
Hs Code.:

Carbamic acid,
[(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy)
methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy) methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy) methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [(1R,2S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[(4-methoxyphenoxy) methyl]-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 596128-77-7
N-[2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenoxymethyl)-propyl]-acetamide

: 596128-78-8
[2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenoxymethyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: di-tert-butyl dicarbonate; N-[2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenoxymethyl)-propyl]-acetamide; With dmap; In tetrahydrofuran; at 70 ℃; for 4h;

With hydrazine hydrate; In methanol; at 25 ℃; for 4h;
DOI:10.1016/S0040-4039(03)01208-5

Reference yield:

: 544455-39-2
(2S,3R)-3-Acetylamino-2-hydroxy-4-(4-methoxy-phenoxy)-butyric acid ethyl ester

: 596128-78-8
[2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenoxymethyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / NaH / dimethylformamide / 10 h / 0 °C

2.1: 100 percent / LiBH₄ / diethyl ether / 0.25 h

3.1: 95 percent / TEA; DMAP / CH₂Cl₂ / 4 h / 25 °C

4.1: DMAP / tetrahydrofuran / 4 h / 70 °C

4.2: 90 percent / hydrazine hydrate / methanol / 4 h / 25 °C

With dmap; lithium borohydride; TEA; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)01208-5

Reference yield:

: 596128-75-5
N-[(1R,2S)-2-Benzyloxy-3-hydroxy-1-(4-methoxy-phenoxymethyl)-propyl]-acetamide

: 596128-78-8
[2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-1-(4-methoxy-phenoxymethyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / TEA; DMAP / CH₂Cl₂ / 4 h / 25 °C

2.1: DMAP / tetrahydrofuran / 4 h / 70 °C

2.2: 90 percent / hydrazine hydrate / methanol / 4 h / 25 °C

With dmap; TEA; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(03)01208-5