phendioxan

Base Information

• Chemical Name: phendioxan
• CAS No.: 130905-04-3
• Molecular Formula: C₂₅H₂₇NO₅
• Molecular Weight: 421.493
• Mol file: 130905-04-3.mol

Synonyms:1,4-Benzodioxin-2-methanamine,N-[2-(2,6-dimethoxyphenoxy)ethyl]-2,3-dihydro-3-phenyl-, trans-

Chemical Property of phendioxan

Chemical Property:

• Vapor Pressure: 1.57E-12mmHg at 25°C
• Boiling Point: 559°Cat760mmHg
• Flash Point: 239.3°C
• PSA: 58.18000
• Density: 1.164g/cm³
• LogP: 4.64440

Purity/Quality:

WB-4101 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phendioxan

There total 6 articles about phendioxan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (21770-51-4) → [2-(2,6-Dimethoxy-phenoxy)-ethyl]-((2S,3R)-3-phenyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine (130905-03-2,130905-04-3,146234-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, EtOCOCl / CHCl₃

2: borane-methylsulfide / bis-(2-methoxy-ethyl) ether

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; In chloroform; diethylene glycol dimethyl ether;

DOI:10.1021/jm00173a004

Reference yield:

3-phenyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (21770-51-4) → phenodioxan (130905-03-2,130905-04-3,146234-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, EtOCOCl / CHCl₃

2: borane-methylsulfide / bis-(2-methoxy-ethyl) ether

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; In chloroform; diethylene glycol dimethyl ether;

DOI:10.1021/jm00173a004

Reference yield:

2-(2,6-dimethoxyphenoxy)ethylamine (40515-98-8) → [2-(2,6-Dimethoxy-phenoxy)-ethyl]-((2S,3R)-3-phenyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine (130905-03-2,130905-04-3,146234-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, EtOCOCl / CHCl₃

2: borane-methylsulfide / bis-(2-methoxy-ethyl) ether

With dimethylsulfide borane complex; chloroformic acid ethyl ester; triethylamine; In chloroform; diethylene glycol dimethyl ether;

DOI:10.1021/jm00173a004

upstream raw materials:

3-Phenyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid [2-(2,6-dimethoxy-phenoxy)-ethyl]-amide

3-phenyl-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid

2-(2,6-dimethoxyphenoxy)ethylamine

Refernces