7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid

Base Information

Chemical Name:7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid
CAS No.:94788-69-9
Molecular Formula:C₁₆H₁₅FN₂O₆S₂
Molecular Weight:414.435
Hs Code.:
DSSTox Substance ID:DTXSID80915305
Mol file:94788-69-9.mol

Synonyms:7(alpha-fluoro-2-thienylacetamido)cephalosporanic acid;L 14655;L-14655

Suppliers and Price of 7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid

Chemical Property:

Vapor Pressure:2.51E-24mmHg at 25°C
Boiling Point:760.7°Cat760mmHg
Flash Point:413.9°C
Density:1.6g/cm³
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:414.03555671
Heavy Atom Count:27
Complexity:715

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CS3)F)SC1)C(=O)O
Isomeric SMILES:CC(=O)OCC1=C(N2C([C@@H](C2=O)NC(=O)C(C3=CC=CS3)F)SC1)C(=O)O

Technology Process of 7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid

There total 7 articles about 7(alpha-Fluoro-2-thienylacetamido)cephalosporanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57382-97-5
ethyl thiophen-2-ylacetate

: 94788-69-9
7-(D,L-α-fluoro-2-thienylacetamido)cephalosporanic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ClFO₃, NaOC₂H₅ / dimethylformamide

2: 71 percent / 85percent KOH / ethanol / Ambient temperature

3: dimethylformamide / -20 °C

4: CH₂Cl₂ / 4 h / -20 °C

With potassium hydroxide; perchloryl fluoride; sodium ethanolate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88798-28-1
diethyl 2-(thiophenyl)propane-1,3-dioate

: 94788-69-9
7-(D,L-α-fluoro-2-thienylacetamido)cephalosporanic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / ClFO₃, NaOC₂H₅ / dimethylformamide / 0 - 7 °C

2: 43.7 percent / LiI / dimethylformamide / 130 °C

3: 71 percent / 85percent KOH / ethanol / Ambient temperature

4: dimethylformamide / -20 °C

5: CH₂Cl₂ / 4 h / -20 °C

With potassium hydroxide; perchloryl fluoride; sodium ethanolate; lithium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 108260-00-0
7-aminocephalosporanic acid

: 94788-69-9
7-(D,L-α-fluoro-2-thienylacetamido)cephalosporanic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1,1,3,3,3-hexamethyldisilazane / CH₂Cl₂ / 3 h / Heating

2: CH₂Cl₂ / 4 h / -20 °C

With 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane;