1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline
CAS No.:96719-61-8
Molecular Formula:C₂₂H₂₀ClNO
Molecular Weight:349.86
Hs Code.:2933499090
DSSTox Substance ID:DTXSID50914365
Mol file:96719-61-8.mol

Synonyms:96719-61-8;1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline;1-(4-CHLOROPHENYL)-6-METHOXY-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE;Isoquinoline, 1,2,3,4-tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenyl-;SCHEMBL6715265;DTXSID50914365;XNRFDMWERXCITN-UHFFFAOYSA-N;LS-85871;1-(4-chloro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-1-(4-CHLOROPHENYL)-6-METHOXY-2-PHENYL- 95.00%
5MG
$ 499.29

Total 2 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline

Chemical Property:

Vapor Pressure:3.32E-10mmHg at 25°C
Boiling Point:501.9°Cat760mmHg
Flash Point:257.4°C
PSA：12.47000
Density:1.199g/cm³
LogP:5.56570
XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:349.1233420
Heavy Atom Count:25
Complexity:416

Purity/Quality:: ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-1-(4-CHLOROPHENYL)-6-METHOXY-2-PHENYL- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(N(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)Cl

Technology Process of 1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline

There total 6 articles about 1,2,3,4-Tetrahydro-1-(4-chlorophenyl)-6-methoxy-2-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96719-24-3
1-(4-Chloro-phenyl)-6-methoxy-2-phenyl-3,4-dihydro-isoquinolinium; iodide

: 96719-61-8
1-(4-Chloro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; Yield given;

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 96719-61-8
1-(4-Chloro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / benzene / 1 h / Heating

2: diethyl ether / Ambient temperature

3: 74 percent / LAH / dioxane; diethyl ether

4: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

5: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

6: NaBH₄ / methanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether; benzene;

Reference yield:

: 51009-27-9
[2-(3-Methoxy-phenyl)-ethyl]-phenyl-amine

: 96719-61-8
1-(4-Chloro-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

2: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

3: NaBH₄ / methanol

With sodium tetrahydroborate; thionyl chloride; potassium iodide; trichlorophosphate; In methanol;