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Technology Process of Diacylglycerol kinase inhibitor i

Diacylglycerol kinase inhibitor i

Base Information
  • Chemical Name:Diacylglycerol kinase inhibitor i
  • CAS No.:93076-89-2
  • Molecular Formula:C27H26 F N3 O S
  • Molecular Weight:459.58
  • Hs Code.:
  • UNII:PF550QIT3I
  • DSSTox Substance ID:DTXSID20239254
  • Nikkaji Number:J326.153K
  • Wikidata:Q27164693
  • ChEMBL ID:CHEMBL259388
  • Mol file:93076-89-2.mol
Diacylglycerol kinase inhibitor i

Synonyms:6-(2-(4-((4-fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one;R 59-022;R 59022;R-59 022;R59022

Suppliers and Price of Diacylglycerol kinase inhibitor i
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • R 59-022
  • 10mg
  • $ 409.00
  • Usbiological
  • R-59-022
  • 1mg
  • $ 312.00
  • TRC
  • R-59-022(DiacylglycerolKinaseInhibitorI)
  • 1mg
  • $ 45.00
  • Tocris
  • R59-022 ≥98%(HPLC)
  • 50
  • $ 670.00
  • Tocris
  • R59-022 ≥98%(HPLC)
  • 10
  • $ 162.00
  • Sigma-Aldrich
  • Diacylglycerol Kinase Inhibitor I solid
  • 1mg
  • $ 106.00
  • Sigma-Aldrich
  • Diacylglycerol Kinase Inhibitor I
  • 5mg
  • $ 129.50
  • Sigma-Aldrich
  • Diacylglycerol Kinase Inhibitor I solid
  • 5mg
  • $ 369.00
  • Medical Isotopes, Inc.
  • R-59-022(DiacylglycerolKinaseInhibitorI)
  • 50 mg
  • $ 940.00
  • ChemScene
  • R59-022 >99.0%
  • 5mg
  • $ 350.00
Total 9 raw suppliers
Chemical Property of Diacylglycerol kinase inhibitor i
Chemical Property:
  • Vapor Pressure:2.75E-15mmHg at 25°C 
  • Boiling Point:619.8°Cat760mmHg 
  • Flash Point:328.6°C 
  • PSA：65.85000 
  • Density:1.26g/cm3 
  • LogP:5.28180 
  • Storage Temp.:−70°C 
  • Solubility.:0.1 M HCl: slightly soluble 
  • XLogP3:5.1
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:5
  • Exact Mass:459.17806180
  • Heavy Atom Count:33
  • Complexity:868
Purity/Quality:

98%,99%, *data from raw suppliers

R 59-022 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 23-24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=CC=C4)C5=CC=C(C=C5)F)CC3
  • Description R-59022 (93076-89-2) is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 μM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4
  • Uses R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.
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