(4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 3-[bis(2-chloroethyl)amino]-4-methylbenzoate

Base Information

• Chemical Name: (4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 3-[bis(2-chloroethyl)amino]-4-methylbenzoate
• CAS No.: 157757-78-3
• Molecular Formula: C₃₁H₄₄Cl₂N₂O₃
• Molecular Weight: 563.608
• Mol file: 157757-78-3.mol

Synonyms:17a-Aza-D-homoandrostan-17-one,3-[[3-[bis(2-chloroethyl)amino]-4-methylbenzoyl]oxy]-, (3b,5a)-

Chemical Property of (4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 3-[bis(2-chloroethyl)amino]-4-methylbenzoate

Chemical Property:

• Vapor Pressure: 3.59E-19mmHg at 25°C
• Boiling Point: 695.1°Cat760mmHg
• Flash Point: 374.2°C
• Density: 1.22g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 3-[bis(2-chloroethyl)amino]-4-methylbenzoate

There total 6 articles about (4aS,4bR,6aS,8S,10aS,10bS,12aS)-10a,12a-dimethyl-2-oxooctadecahydronaphtho[2,1-f]quinolin-8-yl 3-[bis(2-chloroethyl)amino]-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam (39932-99-5) + C24H28Cl4N2O3 (1027067-18-0) → 3β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam 4-methyl-3-N,N-bis(2-chloroethyl)aminobenzoate (157757-78-3)

Guidance literature:

With dmap; In benzene; for 48h;

DOI:10.1002/jhet.5570310219

Reference yield: 63.0%

3α-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam (1704-46-7) + C24H28Cl4N2O3 (1027067-18-0) → 3α-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam 4-methyl-3-N,N-bis(2-chloroethyl)aminobenzoate (157757-78-3)

Guidance literature:

With dmap; In benzene; for 48h;

DOI:10.1002/jhet.5570310219

Reference yield:

3-N,N-bis(2-chloroethyl)amino-4-methyl-benzoyl-chloride (21447-59-6) → 3α-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam 4-methyl-3-N,N-bis(2-chloroethyl)aminobenzoate (157757-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / benzene / 2 h / Heating

2: 63 percent / 4-dimethylaminopyridine / benzene / 48 h

With pyridine; dmap; In benzene;

DOI:10.1002/jhet.5570310219

upstream raw materials:

3α-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam

C₂₄H₂₈Cl₄N₂O₃

4-methyl-3,3-N,N-bis(2-chloroethyl)aminobenzoic acid

3-N,N-bis(2-chloroethyl)amino-4-methyl-benzoyl-chloride