Technology Process of 4-Morpholinecarboxylic acid,
3-[[4-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]phenyl]methyl]-2-oxo-5,
6-diphenyl-, phenylmethyl ester, (3S,5S,6R)-
There total 4 articles about 4-Morpholinecarboxylic acid,
3-[[4-[[bis(1,1-dimethylethoxy)phosphinyl]methyl]phenyl]methyl]-2-oxo-5,
6-diphenyl-, phenylmethyl ester, (3S,5S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 0.5h;
(4-bromomethylbenzyl)phosphonic acid di-tert-butyl ester;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
for 3h;
DOI:10.1021/ol035078+
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / NaH / tetrahydrofuran / 20 h / Heating
2.1: 67 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 3 h / Heating
3.1: NaHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -78 °C
3.2: 78 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C
With
N-Bromosuccinimide; sodium hexamethyldisilazane; sodium hydride; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ol035078+
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / NaH / tetrahydrofuran / 20 h / Heating
2.1: 67 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 3 h / Heating
3.1: NaHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -78 °C
3.2: 78 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / -78 °C
With
N-Bromosuccinimide; sodium hexamethyldisilazane; sodium hydride; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ol035078+
