6-Hydroxy-6,7,4'-trimethylkaempferol

Base Information

• Chemical Name: 6-Hydroxy-6,7,4'-trimethylkaempferol
• CAS No.: 4324-53-2
• Molecular Formula: C18H16O7
• Molecular Weight: 344.32
• Mol file: 4324-53-2.mol

Synonyms:3,5-Dihydroxy-6,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one;

Chemical Property of 6-Hydroxy-6,7,4'-trimethylkaempferol

Chemical Property:

• Boiling Point: 558.8±50.0 °C(Predicted)
• PKA: 6.14±0.40(Predicted)
• PSA: 98.36000
• Density: 1.407±0.06 g/cm3(Predicted)
• LogP: 2.89700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Hydroxy-6,7,4'-trimethylkaempferol

There total 6 articles about 6-Hydroxy-6,7,4'-trimethylkaempferol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Toluene-4-sulfonic acid 3-hydroxy-6,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester (124909-96-2) → 3,5-dihydroxy-6,7,4'-trimethoxyflavone (4324-53-2)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Heating;

Reference yield:

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone (14639-73-7) → 3,5-dihydroxy-6,7,4'-trimethoxyflavone (4324-53-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) potassium benzoate, 2.) K₂CO₃ / 1.) 170/180 deg C, 8 h, 2.) acetone, reflux, 2.5-4 h

2: 93 percent / AlBr₃ / acetonitrile / 0.33 h / 0 - 5 °C

3: 89 percent / K₂CO₃ / acetone / Heating

4: 88 percent / AlBr₃ / acetonitrile / 1 h / Ambient temperature

5: 80 percent / K₂CO₃ / methanol / 2 h / Heating

With aluminum tri-bromide; Potassium benzoate; potassium carbonate; In methanol; acetone; acetonitrile;

Reference yield:

5-hydroxy-3,4',6,7-tetramethoxyflavone (14787-34-9) → 3,5-dihydroxy-6,7,4'-trimethoxyflavone (4324-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / K₂CO₃ / acetone / Heating

2: 88 percent / AlBr₃ / acetonitrile / 1 h / Ambient temperature

3: 80 percent / K₂CO₃ / methanol / 2 h / Heating

With aluminum tri-bromide; potassium carbonate; In methanol; acetone; acetonitrile;

upstream raw materials:

Toluene-4-sulfonic acid 3-hydroxy-6,7-dimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-5-yl ester

1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone

5-hydroxy-3,4',6,7-tetramethoxyflavone

p-Methoxybenzoic anhydride

Downstream raw materials:

3,5-diacetoxy-6,7-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one

Refernces