Pyrimidine, 2-(methylthio)-4,6-diphenyl-

Base Information

Chemical Name:Pyrimidine, 2-(methylthio)-4,6-diphenyl-
CAS No.:59807-21-5
Molecular Formula:C17H14N2S
Molecular Weight:278.378
Hs Code.:
DSSTox Substance ID:DTXSID00451018
Nikkaji Number:J2.123.352H
Wikidata:Q82270870

Synonyms:Pyrimidine, 2-(methylthio)-4,6-diphenyl-;59807-21-5;2-(Methylthio)-4,6-diphenylpyrimidine;SCHEMBL13133556;DTXSID00451018

Suppliers and Price of Pyrimidine, 2-(methylthio)-4,6-diphenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Pyrimidine, 2-(methylthio)-4,6-diphenyl-

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:278.08776963
Heavy Atom Count:20
Complexity:259

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC(=CC(=N1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Pyrimidine, 2-(methylthio)-4,6-diphenyl-

There total 7 articles about Pyrimidine, 2-(methylthio)-4,6-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 56734-10-2
2-(methylsulfanyl)-4-phenylpyrimidine

: 591-51-5
phenyllithium

: 59807-21-5
2-(methylsulfanyl)-4,6-diphenylpyrimidine

Guidance literature:: 2-(methylsulfanyl)-4-phenylpyrimidine; phenyllithium; In tetrahydrofuran; at 20 ℃; for 4h;

With acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 0.75h;
DOI:10.1021/ja044923w

Reference yield: 83.0%

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 98-80-6
phenylboronic acid

: 59807-21-5
2-(methylsulfanyl)-4,6-diphenylpyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; benzene; at 85 ℃; for 15h; Inert atmosphere;
DOI:10.1039/d0cc00251h

Reference yield:

: 1979-98-2
4,6-dihydroxy-2-methylmercaptopyrimidine

: 59807-21-5
2-(methylsulfanyl)-4,6-diphenylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / TEA / CH₂Cl₂ / 1 h / 0 °C

2: 1.) n-BuLi, 2.) ZnBr₂, 3.) Pd(PPh₃)4

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; TEA; zinc dibromide; In dichloromethane;
DOI:10.3987/COM-93-S39