1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-
CAS No.:599156-29-3
Molecular Formula:C16H21NO3
Molecular Weight:275.348
Hs Code.:

Synonyms:

Suppliers and Price of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

There total 9 articles about 1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-3-hydroxy-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 599156-28-2
tert-butyl N-[(1S,2S)-2-hydroxy-1-phenylbut-3-en-1-yl]-N-(prop-2-en-1-yl)carbamate

: 599156-29-3
(2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/S0040-4039(02)02772-7

Reference yield:

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 599156-29-3
(2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DMSO; (COCl)2; iPr₂NEt / CH₂Cl₂

2: tetrahydrofuran / 2 h / 20 °C

3: 90 percent / imidazole / CH₂Cl₂ / 24 h / 0 - 20 °C

4: 90 percent / NaH / dimethylformamide / 24 h / 0 - 20 °C

5: 85 percent / TBAF; AcOH / tetrahydrofuran / 24 h / 0 - 20 °C

6: 82 percent / Grubbs' catalyst / CH₂Cl₂ / 6 h / 20 °C

With 1H-imidazole; Grubbs catalyst first generation; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Swern oxidation;
DOI:10.1016/S0040-4039(02)02772-7

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 599156-29-3
(2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: AcCl

2: Et₃N / tetrahydrofuran / 8 h / 0 - 20 °C

3: 87 percent / LiCl; NaBH₄; EtOH / tetrahydrofuran / 12 h / 0 - 20 °C

4: DMSO; (COCl)2; iPr₂NEt / CH₂Cl₂

5: tetrahydrofuran / 2 h / 20 °C

6: 90 percent / imidazole / CH₂Cl₂ / 24 h / 0 - 20 °C

7: 90 percent / NaH / dimethylformamide / 24 h / 0 - 20 °C

8: 85 percent / TBAF; AcOH / tetrahydrofuran / 24 h / 0 - 20 °C

9: 82 percent / Grubbs' catalyst / CH₂Cl₂ / 6 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; Grubbs catalyst first generation; oxalyl dichloride; ethanol; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4: Swern oxidation;
DOI:10.1016/S0040-4039(02)02772-7