Carbonic acid, (1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(2-methylpropyl)[(4- nitrophenyl)sulfonyl]amino]methyl]-3-phenylpropyl 2-propenyl ester

Base Information

• Chemical Name: Carbonic acid, (1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(2-methylpropyl)[(4- nitrophenyl)sulfonyl]amino]methyl]-3-phenylpropyl 2-propenyl ester
• CAS No.: 599173-46-3
• Molecular Formula: C29H39N3O9S
• Molecular Weight: 605.709
• Mol file: 599173-46-3.mol

Synonyms:

Chemical Property of Carbonic acid, (1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(2-methylpropyl)[(4- nitrophenyl)sulfonyl]amino]methyl]-3-phenylpropyl 2-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid, (1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(2-methylpropyl)[(4- nitrophenyl)sulfonyl]amino]methyl]-3-phenylpropyl 2-propenyl ester

There total 1 articles about Carbonic acid, (1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[(2-methylpropyl)[(4- nitrophenyl)sulfonyl]amino]methyl]-3-phenylpropyl 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

Allyl chloroformate (2937-50-0) + [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester (191226-98-9) → Carbonic acid allyl ester (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (599173-46-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(03)00463-3

Reference yield:

Carbonic acid allyl ester (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (599173-46-3) → {(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-carbamic acid allyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 20 °C

2: aq. phosphate buffer / tetrahydrofuran / 20 °C / pH 7.0

With phosphate buffer; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(03)00463-3

Reference yield:

Carbonic acid allyl ester (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester (599173-46-3) → N-(4-benzyl-2-oxo-oxazolidin-5-ylmethyl)-N-isobutyl-4-nitro-benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 20 °C

2: aq. phosphate buffer / tetrahydrofuran / 20 °C / pH 7.0

With phosphate buffer; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(03)00463-3

upstream raw materials:

Allyl chloroformate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester