Technology Process of 4-Pentenamide,
2-[(diphenylmethylene)amino]-N-methoxy-N-(phenylmethyl)-, (2R)-
There total 4 articles about 4-Pentenamide,
2-[(diphenylmethylene)amino]-N-methoxy-N-(phenylmethyl)-, (2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide; N-spiro chiral quaternary ammonium bromide;
In
toluene;
at 0 ℃;
for 6h;
DOI:10.1021/ja0459328
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: H2 / Pd/C / methanol / 12 h / 20 °C
2.1: HCl / methanol / 0 - 20 °C
2.2: CH2Cl2 / 6 h / 20 °C
3.1: 99 percent / aq. KOH; N-spiro chiral quaternary ammonium bromide / toluene / 6 h / 0 °C
With
hydrogenchloride; potassium hydroxide; N-spiro chiral quaternary ammonium bromide; hydrogen;
palladium on activated charcoal;
In
methanol; toluene;
DOI:10.1021/ja0459328
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-methylmorpholine; ethyl chloroformate / CH2Cl2 / 0.25 h / 0 °C
1.2: 79 percent / CH2Cl2 / 3.3 h / 0 - 20 °C
2.1: H2 / Pd/C / methanol / 12 h / 20 °C
3.1: HCl / methanol / 0 - 20 °C
3.2: CH2Cl2 / 6 h / 20 °C
4.1: 99 percent / aq. KOH; N-spiro chiral quaternary ammonium bromide / toluene / 6 h / 0 °C
With
4-methyl-morpholine; hydrogenchloride; potassium hydroxide; N-spiro chiral quaternary ammonium bromide; hydrogen; chloroformic acid ethyl ester;
palladium on activated charcoal;
In
methanol; dichloromethane; toluene;
DOI:10.1021/ja0459328
