1H-Indazole-1-carboxylic acid, 5-aMino-3-Methyl-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1H-Indazole-1-carboxylic acid, 5-aMino-3-Methyl-, 1,1-diMethylethyl ester
• CAS No.: 599183-32-1
• Molecular Formula: C13H17N3O2
• Molecular Weight: 247.29300
• Mol file: 599183-32-1.mol

Synonyms:tert-butyl 5-amino-3-methylindazole-1-carboxylate;3-amino-5-cyano-pyridine;N-Boc-5-amino-3-methylindazole;5-Amino-3-cyan-pyridin;tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate;5-AMINO-3-CYANOPYRIDINE;5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole;5-amino-nicotinonitrile;5-Amino-3-pyridinecarbonitrile;

Chemical Property of 1H-Indazole-1-carboxylic acid, 5-aMino-3-Methyl-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 70.14000
• LogP: 3.29130

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1H-Indazole-1-carboxylic acid, 5-aMino-3-Methyl-, 1,1-diMethylethyl ester

There total 2 articles about 1H-Indazole-1-carboxylic acid, 5-aMino-3-Methyl-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 3-methyl-5-nitro-1H-indazole-1-carboxylate (599183-33-2) → tert-butyl 5-amino-3-methyl-1H-indazole-1-carboxylate (599183-32-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1h;

Reference yield: 85.0%

→ tert-butyl 5-amino-3-methyl-1H-indazole-1-carboxylate (599183-32-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1h;

Reference yield:

((S,2S),(R,2R))-1-[(1-methyl-piperid-2-yl)-1-phenyl]methylamine + tert-butyl 5-amino-3-methyl-1H-indazole-1-carboxylate (599183-32-1) + bis(trichloromethyl) carbonate (32315-10-9) → tert-butyl ((S,2S),(R,2R))-3-methyl-5-({[(1-methylpiperid-2-yl)(phenyl)methyl]carbamoyl}amino)indazole-1-carboxylate

Guidance literature:

tert-butyl 5-amino-3-methyl-1H-indazole-1-carboxylate; bis(trichloromethyl) carbonate; With triethylamine; In dichloromethane; at 0 - 20 ℃;

((S,2S),(R,2R))-1-[(1-methyl-piperid-2-yl)-1-phenyl]methylamine; In dichloromethane;

upstream raw materials:

tert-butyl 3-methyl-5-nitro-1H-indazole-1-carboxylate

Downstream raw materials:

N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide

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