2-Octenoic acid, 4-[(2-hydroxy-1-oxododecyl)amino]-, phenylmethyl ester, (2E,4S)-

Base Information

Chemical Name:2-Octenoic acid, 4-[(2-hydroxy-1-oxododecyl)amino]-, phenylmethyl ester, (2E,4S)-
CAS No.:600143-18-8
Molecular Formula:C27H43NO4
Molecular Weight:445.643
Hs Code.:

Synonyms:

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Chemical Property of 2-Octenoic acid, 4-[(2-hydroxy-1-oxododecyl)amino]-, phenylmethyl ester, (2E,4S)-

Chemical Property:

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Technology Process of 2-Octenoic acid, 4-[(2-hydroxy-1-oxododecyl)amino]-, phenylmethyl ester, (2E,4S)-

There total 4 articles about 2-Octenoic acid, 4-[(2-hydroxy-1-oxododecyl)amino]-, phenylmethyl ester, (2E,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116640-17-6,137258-12-9,116640-16-5
tert-butyl [(1S)-1-(hydroxymethyl)pentyl]carbamate

: 600143-18-8
benzyl (E,4S)-4-[(2-hydroxydodecanoyl)amino]oct-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: NaBr; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; aq. NaOCl / NaHCO₃ / toluene; ethyl acetate / 1.25 h / -5 - 0 °C

2: tetrahydrofuran / 1 h / Heating

3: aq. HCl / diethyl ether / 0.5 h / 20 °C

4: Et₃N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; 4-acetylamino-2,2,6,6-tetramethylpiperidine-N-oxyl; sodium hypochlorite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bromide; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene; 2: Wittig reaction;
DOI:10.1021/jm030485c

Reference yield:

: 2984-55-6,37639-47-7
2-hydroxydodecanoic acid

: (E)-(S)-4-Amino-oct-2-enoic acid benzyl ester; hydrochloride

: 600143-18-8
benzyl (E,4S)-4-[(2-hydroxydodecanoyl)amino]oct-2-enoate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1021/jm025538p

Reference yield:

: 104062-70-6,440125-24-6
(S)-N-Boc-leucinal

: 600143-18-8
benzyl (E,4S)-4-[(2-hydroxydodecanoyl)amino]oct-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / Heating

2: aq. HCl / diethyl ether / 0.5 h / 20 °C

3: Et₃N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Wittig reaction;
DOI:10.1021/jm030485c