Glybuthiazol

Base Information

Chemical Name:Glybuthiazol
CAS No.:535-65-9
Molecular Formula:C12H16N4O2S2
Molecular Weight:312.417
Hs Code.:2935009090
European Community (EC) Number:208-615-8
NSC Number:23010
UNII:35421N8E8W
DSSTox Substance ID:DTXSID4057762
Nikkaji Number:J6.345B
Wikidata:Q27256420
NCI Thesaurus Code:C72803
ChEMBL ID:CHEMBL94087
Mol file:535-65-9.mol

Synonyms:Glybuthiazol;GLYBUTHIAZOLE;Glipasol;Glypasol;Glybuthizolum;RP 2259;535-65-9;Glibutiazol;Glybuthiazolum;Glybuthiazol [INN:DCF];Glibutiazol [INN-Spanish];Glybuthiazolum [INN-Latin];2259 RP;p-Aminobenzenesulfamido-tert-butylthiodiazol;EINECS 208-615-8;NSC 23010;NSC-23010;RP-2259;BRN 0033849;2259 R. P.;DTXSID4057762;UNII-35421N8E8W;C12H16N4O2S2;Glybuthiazol (INN);35421N8E8W;N1-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)sulfanilamide;N(sup 1)-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)sulfanilamide;2259 R.P.;4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;GLYBUTHIAZOL [INN];Benzenesulfonamide, 4-amino-N-(5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl)-;Sulfanilamide, N1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-;Sulfanilamide, N(sup 1)-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-;R. P. 2259;Glybuthiazol(e);GLYBUTHIZOL;Glybuthiazol [DCF:INN];GLYBUTHIAZOLE [MI];CHEMBL94087;SCHEMBL282607;DTXCID5031551;CHEBI:135337;NSC23010;Tox21_113930;Sulfanilamide,3,4-thiadiazol-2-yl)-;NCGC00262937-01;2259 R.P;CAS-535-65-9;2259 R. P;LS-147753;D02462;Q27256420;Benzenesulfonamide,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]-;4-Amino-N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide

Suppliers and Price of Glybuthiazol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
GLYBUTHIAZOL 95.00%
5MG
$ 505.08

Total 9 raw suppliers

Chemical Property of Glybuthiazol

Chemical Property:

Vapor Pressure:2.25E-10mmHg at 25°C
Melting Point:221-223°
Refractive Index:1.6440 (estimate)
Boiling Point:506.3°Cat760mmHg
PKA:5.52±0.50(Predicted)
Flash Point:260°C
PSA：134.59000
Density:1.398g/cm³
LogP:3.95360
Water Solubility.:56.86mg/L(37 oC)
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:312.07146811
Heavy Atom Count:20
Complexity:422

Purity/Quality:

98%min ^*data from raw suppliers

GLYBUTHIAZOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N

Technology Process of Glybuthiazol

There total 4 articles about Glybuthiazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 432539-49-6
N-(4-(N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide

: 535-65-9
4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: N-(4-(N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide; With hydrogenchloride; In water; for 0.5h; Reflux;

With sodium carbonate; In water;
DOI:10.1016/j.bmc.2011.01.049

Reference yield:

: 39222-73-6
2-Amino-5-t-butyl-1,3,4-thiadiazole

: 535-65-9
4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 95 °C

2: hydrogenchloride / water / 0.5 h / Reflux

With pyridine; hydrogenchloride; In water;
DOI:10.1016/j.bmc.2011.01.049

Reference yield:

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 535-65-9
4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 95 °C

2: hydrogenchloride / water / 0.5 h / Reflux

With pyridine; hydrogenchloride; In water;
DOI:10.1016/j.bmc.2011.01.049