Technology Process of Hexanedioic acid, 2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl)-,
1-methyl ester, (2S,3R)-
There total 7 articles about Hexanedioic acid, 2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl)-,
1-methyl ester, (2S,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylsilane; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/jo0340152
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / Pd/C / methanol / 5 h / 20 °C / 760 Torr
2: 1.29 g / K2CO3 / dioxane; H2O / 2 h / 20 °C
3: 93 percent / Et3SiH; trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
With
triethylsilane; hydrogen; potassium carbonate; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/jo0340152
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: CuBr*Me2S / tetrahydrofuran; various solvent(s) / 0.5 h / -45 - -10 °C
1.2: tetrahydrofuran; various solvent(s) / 0.33 h / -15 - -10 °C
1.3: NBS / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
2.1: 850 mg / NaN3 / dimethylformamide / 4 h / 20 °C
3.1: LiOH*H2O; hydrogen peroxide / tetrahydrofuran; H2O / 0.5 h / -5 - 0 °C
4.1: 1.30 g / diethyl ether / 0.33 h / 0 °C
5.1: hydrogen / Pd/C / methanol / 5 h / 20 °C / 760 Torr
6.1: 1.29 g / K2CO3 / dioxane; H2O / 2 h / 20 °C
7.1: 93 percent / Et3SiH; trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C
With
triethylsilane; lithium hydroxide; sodium azide; copper(I) bromide dimethylsulfide complex; hydrogen; dihydrogen peroxide; potassium carbonate; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
1.2: Michael addition;
DOI:10.1021/jo0340152
