Piperidine, 1-[4-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-3-formyl-1-oxobutyl]-4-( 1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-

Base Information

• Chemical Name: Piperidine, 1-[4-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-3-formyl-1-oxobutyl]-4-( 1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-
• CAS No.: 600725-27-7
• Molecular Formula: C26H28ClF3N4O3
• Molecular Weight: 536.982

Synonyms:

Chemical Property of Piperidine, 1-[4-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-3-formyl-1-oxobutyl]-4-( 1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-

Chemical Property:

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Useful:

Technology Process of Piperidine, 1-[4-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-3-formyl-1-oxobutyl]-4-( 1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-

There total 1 articles about Piperidine, 1-[4-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-3-formyl-1-oxobutyl]-4-( 1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-{1-[4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-hydroxymethyl-butyryl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one (600725-26-6) → 2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butyraldehyde (600725-27-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 82.0%

N-pyridin-4-ylmethyl-benzene-1,2-diamine trihydrochloride + 2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butyraldehyde (600725-27-7) → 3-{1-[4-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-yl-methyl-1H-benzimidazol-2-yl)-butyryl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one (600724-94-5)

Guidance literature:

Reference yield: 80.0%

2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butyraldehyde (600725-27-7) + 3-amino-4-<<<1-(tert-butoxycarbonyl)-4-piperidyl>methyl>amino>pyridine (173604-56-3) → C42H50ClF3N8O4

Guidance literature:

With oxygen; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 16h;

upstream raw materials:

3-{1-[4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-hydroxymethyl-butyryl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

Downstream raw materials:

3-(1-{4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-[5-(3-dimethylaminopropyl)-1-ethyl-1H-benzimidazol-2-yl]-butyryl}-piperidin-4-yl)-1,3,4,5-tetra-hydro-1,3-benzodiazepin-2-one

3-(1-{4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-[1-(3-imidazol-1-yl-propyl)-1H-benzimidazol-2-yl]-butyryl}-piperidin-4-yl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

3-(1-{4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-[1-(4-hydroxy-butyl)-1H-benzimidazol-2-yl]-butyryl}-piperidin-4-yl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

3-(1-{4-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-3-[1-(1-methyl-piperidin-3-ylmethyl)-1H-benzimidazol-2-yl]-butyryl}-piperidin-4-yl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

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