Carbamic acid, methyl[1,4,5,6-tetrahydro-2-(methylamino)-4-oxo-1-(phenylmethyl)-5-pyr imidinyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, methyl[1,4,5,6-tetrahydro-2-(methylamino)-4-oxo-1-(phenylmethyl)-5-pyr imidinyl]-, 1,1-dimethylethyl ester
• CAS No.: 601507-10-2
• Molecular Formula: C18H26N4O3
• Molecular Weight: 346.429
• Mol file: 601507-10-2.mol

Synonyms:

Chemical Property of Carbamic acid, methyl[1,4,5,6-tetrahydro-2-(methylamino)-4-oxo-1-(phenylmethyl)-5-pyr imidinyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, methyl[1,4,5,6-tetrahydro-2-(methylamino)-4-oxo-1-(phenylmethyl)-5-pyr imidinyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, methyl[1,4,5,6-tetrahydro-2-(methylamino)-4-oxo-1-(phenylmethyl)-5-pyr imidinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-benzyl-2-imino-3-methyl-4-oxo-hexahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester (601507-08-8) → (1-benzyl-2-methylamino-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester (601507-10-2)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h;

DOI:10.1016/S0040-4039(03)01381-9

Reference yield:

N-tert-butoxycarbonylserine methyl ester (69942-12-7) → (1-benzyl-2-methylamino-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester (601507-10-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: MsCl; TEA / CH₂Cl₂

1.2: 83 percent / Ag₂O / dimethylformamide / 55 °C

2.1: 50 percent / K₂CO₃ / propan-2-ol

3.1: K₂CO₃ / dimethylformamide / 4 h / 20 °C

4.1: 275 mg / K₂CO₃ / methanol / 3 h / 20 °C

With TEA; potassium carbonate; methanesulfonyl chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/S0040-4039(03)01381-9

Reference yield:

N-Boc-N-methyl-dehydroalanine methyl ester (56776-34-2) → (1-benzyl-2-methylamino-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester (601507-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / K₂CO₃ / propan-2-ol

2: K₂CO₃ / dimethylformamide / 4 h / 20 °C

3: 275 mg / K₂CO₃ / methanol / 3 h / 20 °C

With potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/S0040-4039(03)01381-9

upstream raw materials:

(1-benzyl-2-imino-3-methyl-4-oxo-hexahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester

N-tert-butoxycarbonylserine methyl ester

N-Boc-N-methyl-dehydroalanine methyl ester

(2-amino-1-benzyl-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-methyl-carbamic acid tert-butyl ester

Downstream raw materials:

[2-(acetyl-methyl-amino)-1-benzyl-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl]-methyl-carbamic acid tert-butyl ester