[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9' -[9H]xanthen]-2-yl]propyl ester

Base Information

Chemical Name:[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9' -[9H]xanthen]-2-yl]propyl ester
CAS No.:601519-69-1
Molecular Formula:C₄₆H₄₈FN₃O₄
Molecular Weight:725.903
Hs Code.:

[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-,
(2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9'
-[9H]xanthen]-2-yl]propyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9' -[9H]xanthen]-2-yl]propyl ester

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Technology Process of [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9' -[9H]xanthen]-2-yl]propyl ester

There total 2 articles about [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (2R)-2-[3',6'-bis(diethylamino)-2,3-dihydro-3-oxospiro[1H-isoindole-1,9' -[9H]xanthen]-2-yl]propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5104-49-4
fluorobiprofen

: 601519-66-8
C₃₁H₃₇N₃O₃

: 601519-69-1
C₄₆H₄₈FN₃O₄

Guidance literature:: With 4-pyrrolidin-1-ylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1246/bcsj.76.1405

Reference yield:

: 81-88-9
rhodamine B

: 601519-69-1
C₄₆H₄₈FN₃O₄

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / 24 h / 170 °C

2: 4-(1-pyrrolidinyl)pyridine; EDC / CH₂Cl₂ / 7 h / 20 °C

With 4-pyrrolidin-1-ylpyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1246/bcsj.76.1405