5-(3-NITROPHENYL)-2-FURALDEHYDE

Base Information

• Chemical Name: 5-(3-NITROPHENYL)-2-FURALDEHYDE
• CAS No.: 13148-43-1
• Molecular Formula: C11H7 N O4
• Molecular Weight: 217.181
• Hs Code.: 29321900
• Mol file: 13148-43-1.mol

Synonyms:2-Furaldehyde,5-(m-nitrophenyl)- (8CI); 5-(3-Nitrophenyl)-2-furaldehyde;5-(3-Nitrophenyl)-2-furancarboxaldehyde; 5-(3-Nitrophenyl)furfural;5-(m-Nitrophenyl)-2-furaldehyde; 5-(m-Nitrophenyl)-2-furancarboxaldehyde;5-(m-Nitrophenyl)furfural

Chemical Property of 5-(3-NITROPHENYL)-2-FURALDEHYDE

Chemical Property:

• Appearance/Colour: Yellow powder
• Vapor Pressure: 8.61E-07mmHg at 25°C
• Melting Point: 156-158 °C(lit.)
• Boiling Point: 405.7 °C at 760 mmHg
• Flash Point: 199.1 °C
• PSA: 76.03000
• Density: 1.348 g/cm³
• LogP: 3.19050

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(3-Nitrophenyl)-2-furaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-NITROPHENYL)-2-FURALDEHYDE

There total 10 articles about 5-(3-NITROPHENYL)-2-FURALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

m-iodonitrobenzene (645-00-1) + 5-formylfurane-2-boronic acid (27329-70-0) → 5-(3-nitrophenyl)furfural (13148-43-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 50 ℃; for 1h;

DOI:10.1016/S0968-0896(02)00600-4

Reference yield: 91.0%

m-iodonitrobenzene (645-00-1) + (5-(diethoxymethyl)furan-2-yl)boronic acid (378185-02-5) → 5-(3-nitrophenyl)furfural (13148-43-1)

Guidance literature:

With triethylamine; palladium on activated charcoal; In ethanol; at 60 ℃; for 2h;

DOI:10.1055/s-2001-16759

Reference yield: 90.0%

m-iodonitrobenzene (645-00-1) + 5-tri-n-butylstannyl-2-furannecarbaldehyde → 5-(3-nitrophenyl)furfural (13148-43-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 50 ℃; for 18h;

DOI:10.1016/S0968-0896(02)00600-4

upstream raw materials:

furfural

3-nitro-aniline

m-iodonitrobenzene

(5-(diethoxymethyl)furan-2-yl)boronic acid

Downstream raw materials:

diethyl 2,6-dimethyl-4-[5'-(3''-nitrophenyl)furan-2'-yl]-1,4-dihydropyridine-3,5-dicarboxylate

2,6-Dimethyl-4-[5-(3-nitro-phenyl)-furan-2-yl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

(E)-3-(5-(3-nitrophenyl)furan-2-yl)acrylic acid

2-(1H-benzoimidazol-2-yl)-3-[5-(3-nitro-phenyl)-furan-2-yl]-acrylonitrile

Refernces

• 1、 Ambika,Singh, Pradeep Pratap. "Carbon–Carbon Bond Formation for the Synthesis of 5-Aryl-2-Substituted Furans Catalyzed by K3[Fe(CN)6]". . . Retrieved 2021/10/05.
• 2、 Zafar, Ansa Madeeha,Aslam, Samina,Khakwani, Samia,Khan, Muhammad Naeem,Munawar, Munawar Ali,Khan, Misbahul Ain. "Multicomponent one pot synthesis and characterization of novel 4-furyl-1,4-dihydropyridines". . p. 735 - 741. Retrieved 2017/02/10.