Leukotriene A4

Base Information

Chemical Name:Leukotriene A4
CAS No.:72059-45-1
Molecular Formula:C₂₀H₃₀O₃
Molecular Weight:318.456
Hs Code.:
UNII:7Y7MPZ6563
DSSTox Substance ID:DTXSID40903945
Nikkaji Number:J138.393K
Wikipedia:Leukotriene_A4
Wikidata:Q3024044
Metabolomics Workbench ID:2581
ChEMBL ID:CHEMBL69439
Mol file:72059-45-1.mol

Synonyms:Leukotriene A;Leukotriene A 4;Leukotriene A-4;Leukotriene A4;Leukotrienes A;LTA4

Suppliers and Price of Leukotriene A4

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
LTA4
50μg
$ 573.00

American Custom Chemicals Corporation
LEUKOTRIENE A4 95.00%
5MG
$ 503.15

Total 1 raw suppliers

Chemical Property of Leukotriene A4

Chemical Property:

Vapor Pressure:1.04E-10mmHg at 25°C
Melting Point:28-32°
Boiling Point:484.3°C at 760 mmHg
Flash Point:165.1°C
PSA：49.83000
Density:1.034g/cm³
LogP:5.20390
XLogP3:5.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:13
Exact Mass:318.21949481
Heavy Atom Count:23
Complexity:432

Purity/Quality:

97% ^*data from raw suppliers

LTA4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)O
Isomeric SMILES:CCCCC/C=C\C/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)O

Technology Process of Leukotriene A4

There total 14 articles about Leukotriene A4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 74448-21-8,74497-08-8,81075-82-3,81075-83-4,118333-86-1,118333-88-3
rac-trans-(2E,4E)-3-(1,3-tetradecadiene-5,8-diynyl)oxiranebutanoic acid methyl ester

: 71548-17-9,72059-45-1,74497-09-9,76375-76-3,77341-35-6,114129-55-4,114129-56-5,114129-57-6
(+/-)-LTA

Guidance literature:: With hydrogen; Lindlar's catalyst; In hexane;
DOI:10.1021/ja00536a066

Reference yield:

: 71774-08-8
5(S)-HPETE

: 71548-17-9,72059-45-1,74497-09-9,76375-76-3,77341-35-6,114129-55-4,114129-56-5,114129-57-6
6-epi-Leukotriene A₄

Guidance literature:: potato 5-S LO; In ethanol; at 25 ℃; for 0.75h; pH 8.0 buffer;
DOI:10.1021/ja00186a046

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 71548-17-9,72059-45-1,74497-09-9,76375-76-3,77341-35-6,114129-55-4,114129-56-5,114129-57-6
6-epi-Leukotriene A₄

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1 M potassium carbonate, 2.) O₂ / 2.) potato lipoxygenase / 1.) CH₃OH, 2.) 60 atm, 4 min

2: coral 8-R-LO / ethanol / 0.75 h / 25 °C / pH 8.0 buffer

With oxygen; potassium carbonate; coral 8-R-LO; potato lipoxygenase; In ethanol;
DOI:10.1021/ja00186a046