3-Pyridinecarboxylic acid, 6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester
CAS No.:603122-19-6
Molecular Formula:C31H35ClN2O6
Molecular Weight:567.082
Hs Code.:

3-Pyridinecarboxylic acid,
6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy)
carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 3-Pyridinecarboxylic acid, 6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester

There total 9 articles about 3-Pyridinecarboxylic acid, 6-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1,1-dimethylethoxy) carbonyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 49608-01-7
6-chloro-3-pyridinecarboxylic acid ethyl ester

: 121489-29-0
tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

: 603122-19-6
6-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid ethyl ester

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 20 - 80 ℃; for 2h;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603122-19-6
6-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: potassium carbonate / dimethyl sulfoxide / 2 h / 20 - 80 °C

With palladium 10% on activated carbon; hydrogen; boron tribromide; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm800222k

Reference yield:

: 603122-70-9
(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol

: 603122-19-6
6-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-tert-butyloxycarbonylamino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]nicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h

2: ethanol / Reflux

3: tetrahydrofuran / 20 °C

4: potassium carbonate / dimethyl sulfoxide / 2 h / 20 - 80 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm800222k