Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6, 7,8-tetrahydro-2-naphthalenyl]oxy]-, hydrochloride

Base Information

Chemical Name:Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6, 7,8-tetrahydro-2-naphthalenyl]oxy]-, hydrochloride
CAS No.:603123-60-0
Molecular Formula:C25H23Cl2NO4.ClH
Molecular Weight:508.829
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6, 7,8-tetrahydro-2-naphthalenyl]oxy]-, hydrochloride

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Technology Process of Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6, 7,8-tetrahydro-2-naphthalenyl]oxy]-, hydrochloride

There total 10 articles about Benzoic acid, 2-chloro-5-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6, 7,8-tetrahydro-2-naphthalenyl]oxy]-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603123-96-2
C₃₀H₃₁Cl₂NO₆

: 603123-60-0
2-chloro-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 603123-95-1
C₃₁H₃₃Cl₂NO₆

: 603123-60-0
2-chloro-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium hydroxide; water / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; In 1,4-dioxane;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603123-60-0
2-chloro-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: methanol; sodium hydroxide; water / 20 °C

7: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; palladium 10% on activated carbon; water; hydrogen; copper diacetate; boron tribromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k