Technology Process of Benzoic acid,
3-[[(7S)-7-[[(1,1-dimethylethoxy)carbonyl][(2R)-2-hydroxy-2-(3-pyridinyl)
ethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-
There total 13 articles about Benzoic acid,
3-[[(7S)-7-[[(1,1-dimethylethoxy)carbonyl][(2R)-2-hydroxy-2-(3-pyridinyl)
ethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonium acetate;
In
methanol; water;
Reflux;
DOI:10.1021/jm800222k
- Guidance literature:
-
Multi-step reaction with 10 steps
1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h
3: sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C / pH 7 - 8
4: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere
6: palladium 10% on activated carbon; hydrogen / methanol / 1 h
7: ethanol / Reflux
8: tetrahydrofuran / 20 °C
9: sodium hydroxide; ethanol; water / 2 h / 20 °C
10: palladium 10% on activated carbon; ammonium acetate / methanol; water / Reflux
With
2,6-dimethylpyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); ethanol; palladium 10% on activated carbon; ammonium acetate; water; hydrogen; boron tribromide; sodium carbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
5: Suzuki coupling;
DOI:10.1021/jm800222k
- Guidance literature:
-
Multi-step reaction with 9 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 2 h
2: sodium hydroxide / tetrahydrofuran; water / 1 h / 20 °C / pH 7 - 8
3: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water / 2 h / 20 - 80 °C / Inert atmosphere
5: palladium 10% on activated carbon; hydrogen / methanol / 1 h
6: ethanol / Reflux
7: tetrahydrofuran / 20 °C
8: sodium hydroxide; ethanol; water / 2 h / 20 °C
9: palladium 10% on activated carbon; ammonium acetate / methanol; water / Reflux
With
2,6-dimethylpyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); ethanol; palladium 10% on activated carbon; ammonium acetate; water; hydrogen; sodium carbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
4: Suzuki coupling;
DOI:10.1021/jm800222k
