Chemical Property of CID 558009
Chemical Property:
- Vapor Pressure:3.51E-17mmHg at 25°C
- Refractive Index:1.588
- Boiling Point:638.6 °C at 760 mmHg
- PKA:13.54±0.60(Predicted)
- Flash Point:206.4 °C
- PSA：101.91000
- Density:1.28 g/cm3
- LogP:4.43340
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:4.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:7
- Exact Mass:514.22028266
- Heavy Atom Count:37
- Complexity:833
- Purity/Quality:
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99%, *data from raw suppliers
Schizantherin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC=C(C)C(=O)OC1C2=CC(=C(C(=C2C3=C(C4=C(C=C3CC(C1(C)O)C)OCO4)OC)OC)OC)OC
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Description
Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit. It inhibits formation of advanced glycation end products (AGEs) in vitro. STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer''s disease induced by amyloid-β (1-42) . It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity. STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.
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Uses
Schisantherin B is a bioactive of lignans isolated from Schisandra chinesis which protect against cognitive deficits and neurodegeneration induced by Aβ1-42 in mice.
