L-Phenylalaninamide, N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4- methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol ylcarbonyl)butyl]-

Base Information

Chemical Name:L-Phenylalaninamide, N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4- methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol ylcarbonyl)butyl]-
CAS No.:603137-76-4
Molecular Formula:C₄₄H₅₀FN₇O₈S₃
Molecular Weight:920.12
Hs Code.:

L-Phenylalaninamide,
N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4-
methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol
ylcarbonyl)butyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Phenylalaninamide, N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4- methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol ylcarbonyl)butyl]-

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Technology Process of L-Phenylalaninamide, N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4- methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol ylcarbonyl)butyl]-

There total 6 articles about L-Phenylalaninamide, N-[(phenylmethyl)sulfonyl]-D-phenylalanyl-2-fluoro-N-[(1S)-4-[[imino[[(4- methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]amino]-1-(2-thiazol ylcarbonyl)butyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603137-50-4
C₃₃H₄₅FN₆O₇S₂

: 603137-76-4
C₄₄H₅₀FN₇O₈S₃

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / dioxane / 3 h / 20 °C

2: PS-DIEA resin / CH₂Cl₂; dimethylformamide / 6 h

3: Dess-Martin periodinane / CH₂Cl₂ / 2 h

With hydrogenchloride; PS-DIEA resin; Dess-Martin periodane; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030130t

Reference yield:

: 114873-00-6,114873-10-8
N^α-Boc-o-fluoro-L-phenylalanine

: 603137-76-4
C₄₄H₅₀FN₇O₈S₃

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-diisopropylethylamine; PS-carbodiimide resin / CH₂Cl₂; dimethylformamide / 0.25 h

2: PS-DIEA resin / CH₂Cl₂; dimethylformamide / 3.5 h

3: HCl / dioxane / 3 h / 20 °C

4: PS-DIEA resin / CH₂Cl₂; dimethylformamide / 6 h

5: Dess-Martin periodinane / CH₂Cl₂ / 2 h

With hydrogenchloride; PS-carbodiimide resin; PS-DIEA resin; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030130t

Reference yield:

: 177583-41-4
N-(benzylsulfonyl)-D-phenylalanine

: 603137-76-4
C₄₄H₅₀FN₇O₈S₃

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine; PS-carbodiimide resin / CH₂Cl₂; dimethylformamide / 0.25 h

2: PS-DIEA resin / CH₂Cl₂; dimethylformamide / 6 h

3: Dess-Martin periodinane / CH₂Cl₂ / 2 h

With PS-carbodiimide resin; PS-DIEA resin; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030130t