Cyclopentanecarboxaldehyde, 1-(2-methoxy-5-methylphenyl)-2,2-dimethyl-

Base Information

Chemical Name:Cyclopentanecarboxaldehyde, 1-(2-methoxy-5-methylphenyl)-2,2-dimethyl-
CAS No.:603985-12-2
Molecular Formula:C16H22O2
Molecular Weight:246.349
Hs Code.:

Synonyms:

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Chemical Property of Cyclopentanecarboxaldehyde, 1-(2-methoxy-5-methylphenyl)-2,2-dimethyl-

Chemical Property:

Purity/Quality:

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Technology Process of Cyclopentanecarboxaldehyde, 1-(2-methoxy-5-methylphenyl)-2,2-dimethyl-

There total 22 articles about Cyclopentanecarboxaldehyde, 1-(2-methoxy-5-methylphenyl)-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 815620-64-5
[1-(2'-methoxy-5'-methylphenyl)-2,2-dimethylcyclopentyl]-methanol

: 603985-12-2
1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-cyclopentanecarbaldehyde

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1055/s-2005-865223

Reference yield:

: 858128-74-2
2-(2-methoxy-5-methyl-phenyl)-pent-4-enoic acid

: 603985-12-2
1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: 92 percent / DCC; DMAP / CH₂Cl₂ / 4 h / 20 °C

2.1: LDA / tetrahydrofuran

2.2: 77 percent / Et₃N / tetrahydrofuran / 5.5 h / -70 - 20 °C

3.1: Et₃N / tetrahydrofuran / 2 h / Heating

3.2: aq. HCl / tetrahydrofuran / 0.67 h

4.1: diethyl ether / 0.5 h / 0 °C

5.1: 98 percent / [Cl₂Ru(PCy₃)2=CHPh] / CH₂Cl₂ / 5 h / 20 °C

6.1: 100 percent / H₂ / Pd/C / ethanol / 5 h / 760 Torr

7.1: 97 percent / LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

8.1: 90 percent / PCC; silica gel / CH₂Cl₂ / 0.5 h / 20 °C

With dmap; lithium aluminium tetrahydride; hydrogen; silica gel; triethylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 3.1: Ireland ester Claisen rearrangement;
DOI:10.1055/s-2005-865223

Reference yield:

: 858128-77-5
methyl 2,2-dimethyl-1-(2-methoxy-5-methylphenyl)cyclopent-3-enecarboxylate

: 603985-12-2
1-(2-methoxy-5-methyl-phenyl)-2,2-dimethyl-cyclopentanecarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / ethanol / 5 h / 760 Torr

2: 97 percent / LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

3: 90 percent / PCC; silica gel / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; silica gel; pyridinium chlorochromate; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2005-865223