Chemical Property of Dynorphins
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Chemical Property:
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
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Biological functions
Based on the localization of KOR expression, dynorphins are involved in learning and memory, emotional
control, stress response, and pain. Administration of
high-efficacy KOR agonist caused depressant-like effects
and anhedonia in rodents.?Absence of KOR does not modify expression of the
other components of the opioid system, and behavioral
tests indicate that spontaneous activity is not affected
in mutant mice. KOR is implicated in the perception of
visceral chemical pain. KOR is critical for mediating the
hypolocomotor, analgesic, and aversive actions of a
KOR agonist. This receptor does not contribute to morphine analgesia and reward, but participates in the
expression of morphine abstinence.
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Description
Dynorphin is an extraordinarily potent opioid peptide. To
denote its powerful potency, the peptide was named
“dynorphin” (“dyn” from the Greek dynamis=power and
“orphin” for endogenous morphine peptide). α-Neoendorphin has been identified as a “big” leucine enkephalin
(Leu-ENK) with potent opiate activity.
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Clinical Use
Hydromorphone, morphine, fentanyl, etc., are used to
treat moderate to severe pain. The antagonist buprenorphine is used to treat severe pain, and to ameliorate opioid dependence. Naltrexone is used alongside behavioral
therapy both for opiate addiction and for alcohol dependency. Naloxone is used to reverse narcotic depression.
