Benzeneacetic acid, a-hydroxy-a-phenyl-, 4-piperidinyl ester, hydrochloride

Base Information

• Chemical Name: Benzeneacetic acid, a-hydroxy-a-phenyl-, 4-piperidinyl ester, hydrochloride
• CAS No.: 60573-79-7
• Molecular Formula: C19H21NO3.ClH
• Molecular Weight: 347.842
• Mol file: 60573-79-7.mol

Synonyms:

Chemical Property of Benzeneacetic acid, a-hydroxy-a-phenyl-, 4-piperidinyl ester, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-hydroxy-a-phenyl-, 4-piperidinyl ester, hydrochloride

There total 3 articles about Benzeneacetic acid, a-hydroxy-a-phenyl-, 4-piperidinyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-benzylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate (118108-61-5) → 4-piperidinyl 2-hydroxy-2,2-diphenylacetate hydrochloride (60573-79-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; at 30 ℃; for 4h;

Reference yield:

methyl benzilate (76-89-1) → 4-piperidinyl 2-hydroxy-2,2-diphenylacetate hydrochloride (60573-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 67.6 percent / 10 percent CH₃ONa / petroleum ether; methanol / 4.5 h / Heating

2: 93 percent / H₂ / 10 percent Pd/C / methanol; acetic acid / 4 h / 30 °C

With hydrogen; sodium methylate; palladium on activated charcoal; In methanol; acetic acid; Petroleum ether;

Reference yield:

→ 4-piperidinyl 2-hydroxy-2,2-diphenylacetate hydrochloride (60573-79-7)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 20 ℃;

upstream raw materials:

1-benzylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate

methyl benzilate

Downstream raw materials:

Diphenyl<1-(3-hydroxypropoxy)>essigsaeure-piperid-4'-yl-esterhydrochlorid

Diphenyl(1-propoxy)essigsaeure-piperid-4'-yl-esterhydrochlorid

Refernces

• 1、 Scheithauer. "Synthesis of some metabolites of the bladder spasmolytic propiverine hydrochloride (Mictonorm)". . p. 86 - 90. Retrieved 2007/10/02.