6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

Base Information

Chemical Name:6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide
CAS No.:60656-74-8
Molecular Formula:C₁₅H₉Cl₂FN₂O
Molecular Weight:323.154
Hs Code.:
Mol file:60656-74-8.mol

Synonyms:6-Chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide;

Suppliers and Price of 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline3-Oxide
1g
$ 1320.00

TRC
6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline3-Oxide
100mg
$ 165.00

Medical Isotopes, Inc.
6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline3-Oxide
1 g
$ 2200.00

Total 4 raw suppliers

Chemical Property of 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

Chemical Property:

Melting Point:154 - 158 °C
PSA：38.35000
LogP:4.86160
Solubility.:Acetone, Chloroform, DCM

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline3-Oxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 6-Chloro-2-(chloromethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide is an intermediate in the synthesis of the synthetic precursor of Midazolam (M343000), an anesthetic, anticonvulsant, sedative and hypotic agent.

Technology Process of 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide

There total 1 articles about 6-Chloro-2-(chloroMethyl)-4-(2-fluorophenyl)quinazoline 3-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

Guidance literature:: Dihydroverb.2b, MnO2;

Reference yield: 30.0%

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

: 75-05-8,26809-02-9
acetonitrile

: 109774-09-6
6-chloro-2-chloromethyl-4-(2-fluorophenyl)-1,2-dihydroquinazoline-2-acetonitrile 3-oxide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; warming from -50 deg C to room temperature;
DOI:10.1002/jhet.5570230509

Reference yield:

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

: 109774-23-4
8-chloro-6-(2-fluorophenyl)-N,N-dimethyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, below -50 deg C 2) warming to room temperature, 1 h

2: PCl₃ / CH₂Cl₂ / 0.5 h

3: 70 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

4: 1) H₂, NH₃ / Raney nickel / 1) tetrahydrofuran, ethanol, methanol, atmospheric pressure, 5 h 2) reflux, 5 min

With ammonia; hydrogen; acetic acid; lithium diisopropyl amide; sodium nitrite; phosphorus trichloride; nickel; In dichloromethane;
DOI:10.1002/jhet.5570230509