Methanone, [3-[2-[[3-(dimethylamino)propyl]amino]ethyl]phenyl]phenyl-, dihydrochloride

Base Information

Chemical Name:Methanone, [3-[2-[[3-(dimethylamino)propyl]amino]ethyl]phenyl]phenyl-, dihydrochloride
CAS No.:60695-28-5
Molecular Formula:C₂₀H₂₆N₂O*2ClH
Molecular Weight:383.361
Hs Code.:

Synonyms:

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Chemical Property of Methanone, [3-[2-[[3-(dimethylamino)propyl]amino]ethyl]phenyl]phenyl-, dihydrochloride

Chemical Property:

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Technology Process of Methanone, [3-[2-[[3-(dimethylamino)propyl]amino]ethyl]phenyl]phenyl-, dihydrochloride

There total 8 articles about Methanone, [3-[2-[[3-(dimethylamino)propyl]amino]ethyl]phenyl]phenyl-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81597-86-6
N,N-Dimethyl-N'-{2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl}-propane-1,3-diamine

: 60695-28-5
{3-[2-(3-Dimethylamino-propylamino)-ethyl]-phenyl}-phenyl-methanone; hydrochloride

Guidance literature:: With hydrogenchloride; at 55 - 60 ℃; for 0.75h; Yield given;
DOI:10.1021/jm00378a027

Reference yield:

: 22071-24-5
3-benzoylbenzyl bromide

: 60695-28-5
{3-[2-(3-Dimethylamino-propylamino)-ethyl]-phenyl}-phenyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: dioxane; H₂O / 2.75 h / Heating

2: aq. H₂SO₄ / acetic acid / 3 h / Heating

3: 83.8 g / SOCl₂ / benzene / 2.25 h / Heating

4: triethylamine

5: p-toluenesulfonic acid / benzene / Heating

6: LiAlH₄ / diethyl ether / 3 h

7: 1.5 N hydrochloric acid / 0.75 h / 55 - 60 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; diethyl ether; water; acetic acid; benzene;
DOI:10.1021/jm00378a027

Reference yield:

: 643-65-2
3-methyl benzophenone

: 60695-28-5
{3-[2-(3-Dimethylamino-propylamino)-ethyl]-phenyl}-phenyl-methanone; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: Br₂ / various solvent(s) / 0.5 h / Heating

2: dioxane; H₂O / 2.75 h / Heating

3: aq. H₂SO₄ / acetic acid / 3 h / Heating

4: 83.8 g / SOCl₂ / benzene / 2.25 h / Heating

5: triethylamine

6: p-toluenesulfonic acid / benzene / Heating

7: LiAlH₄ / diethyl ether / 3 h

8: 1.5 N hydrochloric acid / 0.75 h / 55 - 60 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; bromine; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; diethyl ether; water; acetic acid; benzene;
DOI:10.1021/jm00378a027