Cichorine

Base Information

Chemical Name:Cichorine
CAS No.:114090-43-6
Molecular Formula:C₁₀H₁₁NO₃
Molecular Weight:193.202
Hs Code.:
DSSTox Substance ID:DTXSID30331975
Nikkaji Number:J2.206.804K
Wikidata:Q27104923
Metabolomics Workbench ID:52681
Mol file:114090-43-6.mol

Synonyms:6-hydroxy-4-methoxy-5-methyl-2,3-dihydro-1H-isoindol-1-one;cichorine

Suppliers and Price of Cichorine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Cichorine

Chemical Property:

Vapor Pressure:1.33E-11mmHg at 25°C
Boiling Point:524.1°Cat760mmHg
Flash Point:270.8°C
Density:1.29g/cm³
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:193.07389321
Heavy Atom Count:14
Complexity:244

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C2C(=C1OC)CNC2=O)O

Technology Process of Cichorine

There total 12 articles about Cichorine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 863647-53-4
6-isopropoxy-4-methoxy-5-methyl-2,3-dihydro-1H-isoindol-1-one

: 114090-43-6
cichorine

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1039/b504602e

Reference yield:

: 863647-48-7
4-isopropoxy-2-methoxy-3-methylbenzaldehyde

: 114090-43-6
cichorine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 66 percent / toluene / 3 h / Heating

2.1: tBuLi / pentane; diethyl ether / 6 h / 20 °C

2.2: 1,2-dibromotetrachloroethane / pentane; diethyl ether / 12 h / 20 °C

3.1: 1.49 percent / aq. HCl / 0.5 h

4.1: toluene / 3 h / Heating

5.1: 1.39 g / NaBH₄ / methanol / 2 h / 20 °C

6.1: 96 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

7.1: 55 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 °C

8.1: 82 percent / trifluoroacetic acid; anisole / 48 h / Heating

9.1: 78 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

With hydrogenchloride; sodium tetrahydroborate; tert.-butyl lithium; boron trichloride; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1039/b504602e

Reference yield:

: 863647-47-6
2-hydroxy-4-isopropoxy-3-methylbenzaldehyde

: 114090-43-6
cichorine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 57 percent / K₂CO₃ / dimethylformamide / 12 h / 40 °C

2.1: 66 percent / toluene / 3 h / Heating

3.1: tBuLi / pentane; diethyl ether / 6 h / 20 °C

3.2: 1,2-dibromotetrachloroethane / pentane; diethyl ether / 12 h / 20 °C

4.1: 1.49 percent / aq. HCl / 0.5 h

5.1: toluene / 3 h / Heating

6.1: 1.39 g / NaBH₄ / methanol / 2 h / 20 °C

7.1: 96 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

8.1: 55 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 °C

9.1: 82 percent / trifluoroacetic acid; anisole / 48 h / Heating

10.1: 78 percent / BCl₃ / CH₂Cl₂ / 2 h / -78 °C

With hydrogenchloride; sodium tetrahydroborate; tert.-butyl lithium; boron trichloride; potassium carbonate; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; pentane;
DOI:10.1039/b504602e