1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one

Base Information

Chemical Name:1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one
CAS No.:115621-49-3
Molecular Formula:C₁₄H₁₃N₃O
Molecular Weight:239.277
Hs Code.:
Mol file:115621-49-3.mol

Synonyms:1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one

Suppliers and Price of 1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one

Chemical Property:

Vapor Pressure:2.34E-10mmHg at 25°C
Boiling Point:505.9°C at 760 mmHg
Flash Point:259.7°C
PSA：50.41000
Density:1.26g/cm³
LogP:2.05150

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one

There total 11 articles about 1,5-dihydro-4-(4-(1H-imidazol-1-yl)phenyl)-3-methyl-2H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1027537-61-6
4-[3-amino-4-(1H-imidazol-1-yl)phenyl]-1,5-dihydro-3-methyl-2H-pyrrol-2-one

: 115621-49-3
1,5-dihydro-4-[4-(1 H-imidazol-1-yl)phenyl]-3-methyl-2 H-pyrrol-2-one

Guidance literature:: With hydrogenchloride; hypophosphorous acid; copper(II) oxide; sodium nitrite; at 5 ℃; for 1h;
DOI:10.1021/jm00060a012

Reference yield:

: 10040-98-9
1-(4-formylphenyl)-1H-imidazole

: 115621-49-3
1,5-dihydro-4-[4-(1 H-imidazol-1-yl)phenyl]-3-methyl-2 H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / piperidine, acetic acid / benzene / 28 h / Heating

2: 98 percent / tetramethylguanidine / 2 h / -20 °C

3: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

4: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

5: calcium chloride, sodium borohydride / methanol / 4 h

6: pyridine / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 3 h

7: 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / 1.) RT, 1 h, 2.) from RT to 100 deg C, 6 h

With piperidine; pyridine; sodium tetrahydroborate; titanium(III) chloride; 1,1,3,3-tetramethylguanidine; sodium acetate; ammonium formate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; calcium chloride; palladium on activated charcoal; In methanol; water; benzene;
DOI:10.1021/jm00060a012

Reference yield:

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

: 115621-49-3
1,5-dihydro-4-[4-(1 H-imidazol-1-yl)phenyl]-3-methyl-2 H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / tetramethylguanidine / 2 h / -20 °C

2: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

3: 98 percent / titanium trichloride, sodium acetate / H₂O; methanol / 2 h

4: calcium chloride, sodium borohydride / methanol / 4 h

5: pyridine / 1.) 0 deg C, 1 h, 2.) from 0 deg C to RT, 3 h

6: 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / 1.) RT, 1 h, 2.) from RT to 100 deg C, 6 h

With pyridine; sodium tetrahydroborate; titanium(III) chloride; 1,1,3,3-tetramethylguanidine; sodium acetate; ammonium formate; 1,8-diazabicyclo[5.4.0]undec-7-ene; calcium chloride; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00060a012