6-Methyl-1H-purin-2-amine

Base Information

• Chemical Name: 6-Methyl-1H-purin-2-amine
• CAS No.: 1681-10-3
• Molecular Formula: C6H7 N5
• Molecular Weight: 149.155
• Hs Code.: 2933990090
• European Community (EC) Number: 216-857-0
• NSC Number: 30107
• DSSTox Substance ID: DTXSID10168488
• Nikkaji Number: J36.377D
• Mol file: 1681-10-3.mol

Synonyms:6-Methyl-1H-purin-2-amine;1681-10-3;6-methyl-7H-purin-2-amine;Purine, 2-amino-6-methyl-;9H-Purin-2-amine, 6-methyl-;EINECS 216-857-0;2-Amino-6-methylpurine;1H-Purin-2-amine, 6-methyl-;6-methyl-aminopurine;6-methyl-9H-purin-2-amine;SCHEMBL320850;DTXSID10168488;NSC30107;NSC 30107;NSC-30107;AKOS006341705;AKOS027257507;AS-58964;A909690

Chemical Property of 6-Methyl-1H-purin-2-amine

Chemical Property:

• Vapor Pressure: 2.99E-13mmHg at 25°C
• Melting Point: 251 °C
• Boiling Point: 291.8°Cat760mmHg
• PKA: 8.49±0.20(Predicted)
• Flash Point: 130.3°C
• PSA: 80.48000
• Density: 1.71g/cm³
• LogP: 0.82470
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 149.07014524
• Heavy Atom Count: 11
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-1H-purin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=NC(=N1)N)N=CN2

Technology Process of 6-Methyl-1H-purin-2-amine

There total 6 articles about 6-Methyl-1H-purin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

9-benzyl-6-methyl-9H-purin-2-ylamine (228874-35-9) → 2-amino-6-methylpurine (1681-10-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; palladium dichloride; In methanol; for 48h; Ambient temperature;

DOI:10.1021/jm9811256

Reference yield:

→ 2-amino-6-methylpurine (1681-10-3)

Guidance literature:

2-Amino-purin-aldehyd-(6)-thiosemicarbazon, konz NH2-NH2-Lsg.;

DOI:10.1002/cber.19681010231

Reference yield:

6-methyl-2,4,5-triaminopyrimidine (60914-71-8) + formamide (77287-34-4,77287-35-5,60100-09-6) → 6-methyl-7(9)H-purin-2-ylamine (1681-10-3)

Guidance literature:

DOI:10.1021/ja01098a003

upstream raw materials:

6-methyl-2,4,5-triaminopyrimidine

formamide

N-(2,4-diamino-6-methyl-pyrimidin-5-yl)-formamide

9-benzyl-6-methyl-9H-purin-2-ylamine

Refernces

• 1、 Giner-Sorolla. "Preparation and properties of a 6- and 2.6-substituted purine". . p. 611 - 618. Retrieved 2007/10/05.