Cyclo(L-alanyl-L-isoleucyl-L-prolyl-L-phenylalanyl-L-asparaginyl-L-seryl-L-leucyl)(9CI)

Base Information

• Chemical Name: Cyclo(L-alanyl-L-isoleucyl-L-prolyl-L-phenylalanyl-L-asparaginyl-L-seryl-L-leucyl)(9CI)
• CAS No.: 145190-76-7
• Molecular Formula: C36H54 N8 O9
• Molecular Weight: 742.873
• Mol file: 145190-76-7.mol

Synonyms:Stylostatin1; 1H-Pyrrolo[1,2-a][1,4,7,10,13,16,19]heptaazacycloheneicosine, cyclic peptidederiv.

Chemical Property of Cyclo(L-alanyl-L-isoleucyl-L-prolyl-L-phenylalanyl-L-asparaginyl-L-seryl-L-leucyl)(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclo(L-alanyl-L-isoleucyl-L-prolyl-L-phenylalanyl-L-asparaginyl-L-seryl-L-leucyl)(9CI)

There total 7 articles about Cyclo(L-alanyl-L-isoleucyl-L-prolyl-L-phenylalanyl-L-asparaginyl-L-seryl-L-leucyl)(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

H-Pro-Phe-Asn-Ser-Leu-Ala-Ile-OH → stylostatin 1 (145190-76-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -10 ℃; for 2h;

DOI:10.1021/jo9818780

Reference yield: 59.9%

(S)-2-((S)-2-{(S)-2-[((S)-1-{(2S,3S)-2-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-propionylamino]-3-methyl-pentanoyl}-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionylamino}-3-carbamoyl-propionylamino)-3-hydroxy-propionic acid → stylostatin 1 (145190-76-7)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2003.11.107

Reference yield: 50.0%

H-Phe-Asn-Ser-Leu-Ala-Ile-Pro-OH → stylostatin 1 (145190-76-7)

Guidance literature:

With benzotriazol-1-yl-oxy-tris-pyrrolidinophosphonium; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

DOI:10.1021/jm030943h

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-isoleucine

L-N-Boc-Ala

(S)-N-(tert-butoxycarbonyl)serine

N-tert-butoxycarbonyl-L-phenylalanine