2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-

Base Information

Chemical Name:2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-
CAS No.:610272-49-6
Molecular Formula:C11H13F3O3
Molecular Weight:250.21400
Hs Code.:
DSSTox Substance ID:DTXSID10450552
Nikkaji Number:J1.955.630A
Wikidata:Q82270334

Synonyms:610272-49-6;(2R,3S)-4-(BENZYLOXY)-1,1,1-TRIFLUOROBUTANE-2,3-DIOL;2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-;DTXSID10450552;(2R,3S)-1,1,1-Trifluoro-4-(benzyloxy)butane-2,3-diol

Suppliers and Price of 2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-

Chemical Property:

PSA：49.69000
LogP:1.48730
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:250.08167876
Heavy Atom Count:17
Complexity:215

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COCC(C(C(F)(F)F)O)O
Isomeric SMILES:C1=CC=C(C=C1)COC[C@@H]([C@H](C(F)(F)F)O)O

Technology Process of 2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)-

There total 2 articles about 2,3-Butanediol, 1,1,1-trifluoro-4-(phenylmethoxy)-, (2R,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610272-47-4
(E)-(((4,4,4-trifluorobut-2-en-1-yl)oxy)methyl)benzene

: 610272-49-6
(2S,3R)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol

: 610272-58-7
(2R,3S)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol

Guidance literature:: With methanesulfonamide; AD-mix-β; In water; tert-butyl alcohol; at 20 ℃; for 96h; Title compound not separated from byproducts;
DOI:10.1021/jo0344384

Reference yield:

: 610272-48-5
1-[((E)-3-bromoallyloxy)methyl]benzene

: 610272-49-6
(2S,3R)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / CuI / dimethylformamide; hexamethylphosphoric acid triamide / 10 h / 80 °C

2: AD-mix-α; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 96 h / 20 °C

With AD-mix-α; copper(l) iodide; methanesulfonamide; In N,N,N,N,N,N-hexamethylphosphoric triamide; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo0344384