Boronic acid, (5-cyano-2-methoxyphenyl)- (9CI)

Base Information

• Chemical Name: Boronic acid, (5-cyano-2-methoxyphenyl)- (9CI)
• CAS No.: 612833-37-1
• Molecular Formula: C8H8BNO3
• Molecular Weight: 176.967
• Hs Code.: 2931900090
• Mol file: 612833-37-1.mol

Synonyms:cyanomethoxyphenylboronicacid;5-CYANO-2-METHOXYPHENYLBORONIC ACID;2-methoxy-5-cyanophenylboronic acid;

Chemical Property of Boronic acid, (5-cyano-2-methoxyphenyl)- (9CI)

Chemical Property:

• Melting Point: 211-212oC
• Boiling Point: 412.4±55.0 °C(Predicted)
• PKA: 7.19±0.58(Predicted)
• PSA: 73.48000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: -0.75332
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

5-Cyano-2-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boronic acid, (5-cyano-2-methoxyphenyl)- (9CI)

There total 3 articles about Boronic acid, (5-cyano-2-methoxyphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Triisopropyl borate (5419-55-6) + 3-bromo-4-methoxybenzonitrile (117572-79-9) → (5-cyano-2-methoxyphenyl)boronic acid (612833-37-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Reference yield: 78.0%

3-bromo-4-methoxybenzonitrile (117572-79-9) → (5-cyano-2-methoxyphenyl)boronic acid (612833-37-1)

Guidance literature:

3-bromo-4-methoxybenzonitrile; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 1.33333h; Cooling with acetone-dry ice;

With phosphoric acid; In tetrahydrofuran; hexane; water; at -78 - 20 ℃; Cooling with acetone-dry ice;

Reference yield:

→ (5-cyano-2-methoxyphenyl)boronic acid (612833-37-1)

Guidance literature:

upstream raw materials:

3-bromo-4-methoxybenzonitrile

Triisopropyl borate

Downstream raw materials:

3-(1,4-dichloro-isoquinolin-7-yl)-4-methoxy-benzonitrile

N-[4-chloro-7-(5-cyano-2-methoxy-phenyl)-isoquinolin-1-yl]-guanidine

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