Tetrakis(4-formylphenyl)methane

Base Information

• Chemical Name: Tetrakis(4-formylphenyl)methane
• CAS No.: 617706-61-3
• Molecular Formula: C29H20O4
• Molecular Weight: 432.475
• DSSTox Substance ID: DTXSID90514328
• Nikkaji Number: J1.931.488J
• Wikidata: Q82374585
• Mol file: 617706-61-3.mol

Synonyms:617706-61-3;Tetrakis(4-formylphenyl)methane;4-[tris(4-formylphenyl)methyl]benzaldehyde;4,4',4'',4'''-Methanetetrayltetrabenzaldehyde;MFCD12911658;Benzaldehyde, 4,4',4'',4'''-methanetetrayltetrakis-;YSZC075;SCHEMBL19218156;DTXSID90514328;AC8057;BS-48217;SY040629;CS-0110588;FT-0654540;4-[tris(4-methanoylphenyl)methyl]benzaldehyde;10.14272/NKFUMXIARBFRPH-UHFFFAOYSA-N.1;A833412;doi:10.14272/NKFUMXIARBFRPH-UHFFFAOYSA-N.1

Chemical Property of Tetrakis(4-formylphenyl)methane

Chemical Property:

• Melting Point: >180 °C (decomp)(Solv: ethyl acetate (141-78-6))
• Boiling Point: 634.9±55.0 °C(Predicted)
• PSA: 68.28000
• Density: 1.262±0.06 g/cm3(Predicted)
• LogP: 5.31930
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 432.13615911
• Heavy Atom Count: 33
• Complexity: 538

Purity/Quality:

≥99% ^*data from raw suppliers

4-[tris(4-formylphenyl)methyl]benzaldehyde 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=O)C(C2=CC=C(C=C2)C=O)(C3=CC=C(C=C3)C=O)C4=CC=C(C=C4)C=O

Technology Process of Tetrakis(4-formylphenyl)methane

There total 4 articles about Tetrakis(4-formylphenyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

tetrakis(4-bromophenyl)methane (105309-59-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → tetrakis(4-formylphenyl)methane (617706-61-3)

Guidance literature:

tetrakis(4-bromophenyl)methane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 25 ℃; Inert atmosphere;

DOI:10.1002/anie.201712246

Reference yield:

tetraphenylmethane (630-76-2) → tetrakis(4-formylphenyl)methane (617706-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / ethanol / -78 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: -78 - 20 °C

With n-butyllithium; bromine; In tetrahydrofuran; ethanol; hexane;

DOI:10.1002/cplu.201800361

Reference yield:

aniline (62-53-3) → tetrakis(4-formylphenyl)methane (617706-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.25 h / 190 °C

1.2: 0.5 h / 80 °C

2.1: bromine / ethanol / -78 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: -78 - 20 °C

With n-butyllithium; bromine; In tetrahydrofuran; ethanol; hexane;

DOI:10.1002/cplu.201800361

upstream raw materials:

tetrakis(4-bromophenyl)methane

N,N-dimethyl-formamide

tetraphenylmethane

aniline

Downstream raw materials:

C₃₇H₄₄O₄