7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine
• CAS No.: 622402-28-2
• Molecular Formula: C18H13N3
• Molecular Weight: 271.31600
• DSSTox Substance ID: DTXSID80416180
• Wikidata: Q82225368
• ChEMBL ID: CHEMBL423072
• Mol file: 622402-28-2.mol

Synonyms:622402-28-2;7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine;7-phenyl-3-pyridin-4-ylimidazo[1,2-a]pyridine;imidazopyridine 10a;BDBM5297;CHEMBL423072;SCHEMBL5251631;DTXSID80416180;FT-0714977;C16100;4-{7-phenylimidazo[1,2-a]pyridin-3-yl}pyridine

Chemical Property of 7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine

Chemical Property:

• PSA: 30.19000
• LogP: 4.06330
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 271.110947427
• Heavy Atom Count: 21
• Complexity: 333

Purity/Quality:

95+% ^*data from raw suppliers

7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC3=NC=C(N3C=C2)C4=CC=NC=C4

Technology Process of 7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine

There total 5 articles about 7-Phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-phenylimidazo[1,2-a]pyridine (85102-27-8) → 7-phenyl-3-pyridin-4-yl-imidazo[1,2-a]pyridine (622402-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / ICl; AcOH

2: Pd(PPh₃)4; Na₂CO₃ / dioxane / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Iodine monochloride; sodium carbonate; acetic acid; In 1,4-dioxane; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2003.12.007

Reference yield:

tert-butyl (4-phenylpyridin-2-yl)carbamate (622402-25-9) → 7-phenyl-3-pyridin-4-yl-imidazo[1,2-a]pyridine (622402-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / HCl / ethyl acetate

2: 19 percent / aq. NaHCO₃ / 80 °C

3: 72 percent / ICl; AcOH

4: Pd(PPh₃)4; Na₂CO₃ / dioxane / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Iodine monochloride; sodium hydrogencarbonate; sodium carbonate; acetic acid; In 1,4-dioxane; ethyl acetate; 4: Suzuki coupling;

DOI:10.1016/j.bmcl.2003.12.007

Reference yield:

4-pyridylboronic acid (1692-15-5) + 3-iodo-7-phenyl-imidazo[1,2-a]pyridine (622402-26-0) → 7-phenyl-3-pyridin-4-yl-imidazo[1,2-a]pyridine (622402-28-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; Heating;

DOI:10.1016/j.bmcl.2003.12.007

upstream raw materials:

4-pyridylboronic acid

3-iodo-7-phenyl-imidazo[1,2-a]pyridine

4-phenyl-pyridin-2-ylamine

7-phenylimidazo[1,2-a]pyridine

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