4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one

Base Information

Chemical Name:4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one
CAS No.:62263-54-1
Molecular Formula:C₁₁H₈F₃NO₂
Molecular Weight:243.185
Hs Code.:
DSSTox Substance ID:DTXSID20497094

Synonyms:62263-54-1;4-Methyl-4-phenyl-2-(trifluoromethyl)oxazol-5(4H)-one;DTXSID20497094;4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one

Suppliers and Price of 4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one

Chemical Property:

PSA：38.66000
LogP:1.85500
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:243.05071298
Heavy Atom Count:17
Complexity:358

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(=O)OC(=N1)C(F)(F)F)C2=CC=CC=C2

Technology Process of 4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one

There total 2 articles about 4-Methyl-4-phenyl-2-(trifluoromethyl)-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4507-48-6
TFA-DL-Phg(αMe)-OH

: 62263-54-1
4-methyl-4-phenyl-2-trifluoromethyl-4H-oxazol-5-one

Guidance literature:: With thionyl chloride;
DOI:10.1039/jr9650006227

Reference yield:

: 62263-54-1
4-methyl-4-phenyl-2-trifluoromethyl-4H-oxazol-5-one

Guidance literature:: N-Trifluoracetyl-α-phenylalanin, SOCl2;
DOI:10.1021/jo00434a020

Reference yield:

: 62263-54-1
4-methyl-4-phenyl-2-trifluoromethyl-4H-oxazol-5-one

: 4-methyl-4-phenyl-2-[1-phenyl-1-(2,2,2-trifluoro-acetylamino)-ethyl]-4H-oxazol-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile

2: aq. NaOH

3: Ac₂O / Heating

With sodium hydroxide; acetic anhydride; In acetonitrile;
DOI:10.1039/jr9650006227