4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE

Base Information

• Chemical Name: 4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
• CAS No.: 623577-59-3
• Molecular Formula: C9H6BrFN2
• Molecular Weight: 241.062
• Mol file: 623577-59-3.mol

Synonyms:4-Bromo-1-(4-fluorophenyl)-1H-imidazole;

Chemical Property of 4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE

Chemical Property:

• PSA: 17.82000
• LogP: 2.77390
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Bromo-1-(4-fluorophenyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE

There total 1 articles about 4-BROMO-1-(4-FLUORO-PHENYL)-1H-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-bromo-1 H-imidazole (2302-25-2) + 4-fluoroboronic acid (1765-93-1) → 4-bromo-1-(4-fluorophenyl)imidazole (623577-59-3)

Guidance literature:

With di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; oxygen; In dichloromethane; at 20 ℃;

DOI:10.1021/jm900056p

Reference yield: 88.0%

4-bromo-1-(4-fluorophenyl)imidazole (623577-59-3) + C18H23BO3 (849549-65-1) → C22H19FN2O (849549-66-2)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 16.67h;

Reference yield: 88.0%

4-bromo-1-(4-fluorophenyl)imidazole (623577-59-3) + C21H28BF3N2O4S (1159705-91-5) → [6S,9R,11R]-2',3',4',5,5',6,7,8,9,10-decahydro-2-(1-(4-fluorophenyl)-imidazol-4-yl)-5'-(2,2,2-trifluoroethyl)-spiro[6,9-methanobenzocyclooctene-11,3'-[1,2,5]thiadiazole] 1',1'-dioxide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; Inert atmosphere; Reflux;

DOI:10.1021/jm900056p

upstream raw materials:

4-bromo-1 H-imidazole

4-fluoroboronic acid

Downstream raw materials:

C₂₂H₁₉FN₂O

Refernces

• 1、 -. "HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE". Page/Page column 111. . Retrieved 2008/06/13.