CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID
• CAS No.: 54162-90-2
• Molecular Formula: C₇H₁₁NO₂
• Molecular Weight: 141.17
• Hs Code.: 2922498590
• Mol file: 54162-90-2.mol

Synonyms:3-Cyclohexene-1-carboxylicacid, 6-amino-, cis-; cis-2-Amino-4-cyclohexene-1-carboxylic acid

Chemical Property of CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.000744mmHg at 25°C
• Melting Point: 196-199 °C
• Refractive Index: 1.5026 (estimate)
• Boiling Point: 285°Cat760mmHg
• Flash Point: 126.2°C
• PSA: 63.32000
• Density: 1.18g/cm³
• LogP: 1.06480

Purity/Quality:

98%Min ^*data from raw suppliers

cis-6-Amino-cyclohex-3-enecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-43
• Safety Statements: 36/37/39-26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID

There total 3 articles about CIS-2-AMINO-4-CYCLOHEXENE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,2,3,6-tertahydrophthalimide (85-40-5) → (cis)-6-aminocyclohex-3-ene-1-carboxylic acid (54162-90-2,74952-21-9,97945-19-2,98856-64-5,128441-32-7,189125-31-3)

Guidance literature:

With trichloroisocyanuric acid; sodium hydroxide; In water; at 0 ℃; for 1.5h; Reflux;

DOI:10.1016/j.tetlet.2021.153422

Reference yield:

6-carbamoylcyclohex-3-enecarboxylic acid (1469-49-4,2028-12-8) → (cis)-6-aminocyclohex-3-ene-1-carboxylic acid (54162-90-2,74952-21-9,97945-19-2,98856-64-5,128441-32-7,189125-31-3)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; Yield given. Multistep reaction; 1.) 0 deg C; 2.) 0 deg C several h, then 70-75 deg C, 10 min;

DOI:10.1016/S0040-4020(01)96537-8

Reference yield:

trans-2-Carboxamidocyclohex-4-enecarboxylic acid (1469-49-4,2028-12-8) → trans-2-amino-4-cyclohexene-1-carboxylic acid (54162-90-2,74952-21-9,97945-19-2,98856-64-5,128441-32-7,189125-31-3)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; Yield given. Multistep reaction; 1.) 0 deg C; 2.) 0 deg C several h, then 70-75 deg C, 10 min;

DOI:10.1016/S0040-4020(01)96537-8

upstream raw materials:

6-carbamoylcyclohex-3-enecarboxylic acid

1,2,3,6-tertahydrophthalimide

trans-2-Carboxamidocyclohex-4-enecarboxylic acid

Downstream raw materials:

cis-1,4,4a,6,7,8,9,11a-octahydropyrido<2,1-b>quinazolin-11-one

cis-2-(hydroxymethyl)-4-cyclohexenyl-1-amine

(4aR,8aS)-3-Phenyl-2-thioxo-2,3,4a,5,8,8a-hexahydro-1H-quinazolin-4-one

cis-2-(tert-butoxycarbonylamino)-4-cyclohexenecarboxylic acid