Technology Process of Coenzyme Q8
There total 36 articles about Coenzyme Q8 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
257885-61-3
(5E,9E,13E,17E,21E,25E)-6,10,14,18,22,26,30-Heptamethyl-hentriaconta-5,9,13,17,21,25,29-heptaen-1-yne
- Guidance literature:
-
trimethylaluminum; (5E,9E,13E,17E,21E,25E)-6,10,14,18,22,26,30-Heptamethyl-hentriaconta-5,9,13,17,21,25,29-heptaen-1-yne;
With
zirconocene dichloride;
In
hexane; 1,2-dichloro-ethane;
2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone;
With
bis(triphenylphosphine)nickel(II) chloride; n-butyllithium;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja992164p
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 94 percent / NaBH4 / tetrahydrofuran / 0.5 h / -20 °C
2.1: POCl3
3.1: dimethylformamide / 20 °C
4.1: TsOH / methanol / 12 h / 20 °C
5.1: 65 percent / n-BuLi
6.1: 100 percent / LiBHEt3; Pd(dppp)Cl2 / tetrahydrofuran / 3 h / 0 °C
7.1: N-chlorosuccinimide; Me2S / CH2Cl2 / 2.5 h / 0 °C
8.1: 79 percent / n-BuLi
9.1: LiBHEt3; Pd(dppp)Cl2 / tetrahydrofuran
10.1: TBAF / tetrahydrofuran
11.1: Cp2ZrCl2 / 1,2-dichloro-ethane; hexane
11.2: 89 percent / NiCl2(PPh3)2; n-BuLi / tetrahydrofuran; hexane
With
sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; zirconocene dichloride; dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); dimethylsulfide; tetrabutyl ammonium fluoride; lithium triethylborohydride; toluene-4-sulfonic acid; trichlorophosphate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
1.1: Reduction / 2.1: Etherification / 3.1: Substitution / 4.1: Hydrolysis / 5.1: Metallation / 5.2: Alkylation / 6.1: desulfonylation / 7.1: Chlorination / 8.1: Metallation / 8.2: Alkylation / 9.1: desulfonylation / 10.1: desilylation / 11.1: carboalumination / 11.2: Condensation;
DOI:10.1021/ja992164p
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: CuCl2; NaCl; conc. aq. HCl / benzene / 5 h / 50 °C
2.1: 94 percent / NaBH4 / tetrahydrofuran / 0.5 h / -20 °C
3.1: POCl3
4.1: dimethylformamide / 20 °C
5.1: TsOH / methanol / 12 h / 20 °C
6.1: 65 percent / n-BuLi
7.1: 100 percent / LiBHEt3; Pd(dppp)Cl2 / tetrahydrofuran / 3 h / 0 °C
8.1: N-chlorosuccinimide; Me2S / CH2Cl2 / 2.5 h / 0 °C
9.1: 79 percent / n-BuLi
10.1: LiBHEt3; Pd(dppp)Cl2 / tetrahydrofuran
11.1: TBAF / tetrahydrofuran
12.1: Cp2ZrCl2 / 1,2-dichloro-ethane; hexane
12.2: 89 percent / NiCl2(PPh3)2; n-BuLi / tetrahydrofuran; hexane
With
hydrogenchloride; sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; zirconocene dichloride; dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); dimethylsulfide; tetrabutyl ammonium fluoride; lithium triethylborohydride; toluene-4-sulfonic acid; sodium chloride; copper dichloride; trichlorophosphate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
1.1: chlorination; rearrangement / 2.1: Reduction / 3.1: Etherification / 4.1: Substitution / 5.1: Hydrolysis / 6.1: Metallation / 6.2: Alkylation / 7.1: desulfonylation / 8.1: Chlorination / 9.1: Metallation / 9.2: Alkylation / 10.1: desulfonylation / 11.1: desilylation / 12.1: carboalumination / 12.2: Condensation;
DOI:10.1021/ja992164p
