BENZOPHENONE-4-MALEIMIDE

Base Information

• Chemical Name: BENZOPHENONE-4-MALEIMIDE
• CAS No.: 92944-71-3
• Molecular Formula: C17H11 N O3
• Molecular Weight: 277.279
• Hs Code.: 2925190090
• Mol file: 92944-71-3.mol

Synonyms:N-(4-Benzoylphenyl)maleimide

Chemical Property of BENZOPHENONE-4-MALEIMIDE

Chemical Property:

• Vapor Pressure: 4.12E-09mmHg at 25°C
• Melting Point: 155-157oC
• Boiling Point: 472.9°Cat760mmHg
• PKA: -3.80±0.20(Predicted)
• Flash Point: 223.7°C
• PSA: 54.45000
• Density: 1.33g/cm³
• LogP: 2.41200
• Storage Temp.: 2-8°C
• Solubility.: chloroform: 50 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

4-(Maleimido)benzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(N-Maleimido)benzophenone can be used as a sulfhydryl reactive heterobifunctional photocrosslinking reagent. It generates photoactivatable conjugates from thiols Maleimide-containing benzophenone as photoinitiator A heterobifunctional cross-linking reagent containing a sulfhydryl-specific group and a photo-active group. Typically, coupled initially by thioether to molecule containing free sulfhydryl buffered at pH 6.8 (6.5-7.0). Second bonding occurs during UV irradiation (250 nm) via diradical excited state. Benzophenones demonstrate greater specificity for C-H insertion and are more stable in water than analogous reagents. In general they are more efficient in attachment because they may be repeatedly irradiated; however, a more intense irradiation may be required. The benzophenone is not sensitive to

Technology Process of BENZOPHENONE-4-MALEIMIDE

There total 5 articles about BENZOPHENONE-4-MALEIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(4-benzoylphenyl)maleamic acid (304456-51-7) → 1‐(4‐benzoylphenyl)‐1H‐pyrrole‐2,5‐dione (92944-71-3)

Guidance literature:

With sodium acetate; acetic anhydride; at 55 ℃; for 2h;

DOI:10.1007/bf00807643

Reference yield: 80.0%

maleic anhydride (108-31-6) + (4-aminophenyl)(phenyl)methanone (1137-41-3,444317-48-0) → 1‐(4‐benzoylphenyl)‐1H‐pyrrole‐2,5‐dione (92944-71-3)

Guidance literature:

With sodium acetate; acetic anhydride;

DOI:10.1021/acs.jmedchem.6b00267

Reference yield:

(4-aminophenyl)(phenyl)methanone (1137-41-3,444317-48-0) → 1‐(4‐benzoylphenyl)‐1H‐pyrrole‐2,5‐dione (92944-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / acetone; methanol / 2 h / Ambient temperature

2: 94 percent / NaOAc, Ac₂O / 2 h / 55 °C

With sodium acetate; acetic anhydride; In methanol; acetone;

DOI:10.1007/bf00807643

upstream raw materials:

N-(4-benzoylphenyl)maleamic acid

(4-aminophenyl)(phenyl)methanone

maleic anhydride

C₁₇H₁₃NO₄

Downstream raw materials:

C₃₀H₂₁NO₅

C₃₂H₂₃NO₅

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