3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

Base Information

Chemical Name:3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
CAS No.:204005-46-9
Molecular Formula:C15H14N2O
Molecular Weight:238.289
Hs Code.:29339900
DSSTox Substance ID:DTXSID1041132
Wikidata:Q27164831
Pharos Ligand ID:1VWH51TK3TJX
ChEMBL ID:CHEMBL2002702
Mol file:204005-46-9.mol

Synonyms:3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one;2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-;DTXSID1041132;Kinome_2848;3-[(2,4-Dimethylpyrrol-5-yl)methylidene]-indolin-2-one;CHEMBL2002702;HMS3374P03;HMS3651F17;AKOS028108497;SB16592;NCI60_034480;FT-0688745;FT-0771090;3-[(2,4-Dimethylpyrrol-5-yl)methylene]-2-indolinone;Q27164831;3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;3-(3,5-dimethyl-1H-pyrrol-2-ylmethylidene)-1,3-dihydro-indol-2-one;3-(3,5-dimethyl-lH-pyrrol-2-ylmethylidene)-1,3-dihydro-indol-2-one

Suppliers and Price of 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SU 5416
10mg
$ 120.00

Sigma-Aldrich
VEGFR2 Kinase Inhibitor III
1mg
$ 152.00

Sigma-Aldrich
SU 5416 ≥98% (HPLC)
5mg
$ 131.00

Sigma-Aldrich
SU 5416 ≥98% (HPLC)
25mg
$ 452.00

DC Chemicals
Semaxanib(SU5416) >98%
100 mg
$ 200.00

DC Chemicals
Semaxanib(SU5416) >98%
250 mg
$ 400.00

Crysdot
Semaxanib(SU5416) 98+%
100mg
$ 563.00

Crysdot
Semaxanib(SU5416) 98+%
50mg
$ 308.00

ChemScene
Semaxinib 99.96%
10mg
$ 84.00

ChemScene
Semaxinib 99.96%
50mg
$ 228.00

Total 62 raw suppliers

Chemical Property of 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

Chemical Property:

Appearance/Colour:yellow to yellow orange
Vapor Pressure:2E-09mmHg at 25°C
Melting Point:226-228 °C
Refractive Index:1.683
Boiling Point:481.4 °Cat760mmHg
PKA:12.59±0.20(Predicted)
Flash Point:244.9 °C
Density:1.256 g/cm³
Storage Temp.:−20°C
Solubility.:H2O: insoluble
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:238.110613074
Heavy Atom Count:18
Complexity:377

Purity/Quality:

97% ^*data from raw suppliers

SU 5416 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
Uses SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into t umor tissues. SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues. SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4

Technology Process of 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one

There total 2 articles about 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: